Evidence map›Paper›PMID 40664934›Full record

ArticleEJNMMI radiopharmacy and chemistry2025

PET imaging of platelet derived growth factor receptor β in lung fibrosis.

Olivia Wegrzyniak, Francesco Lechi, Johanna Rokka, Bogdan Mitran, Bo Zhang, Ulrika Thelander, John Löfblom, Fredrik Y Frejd, Olle Korsgren, Gaetano Perchiazzi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI radiopharmacy and chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Biodistribution and radiation dosimetry of the PDGFRβ targeting PET tracer [European journal of nuclear medicine and molecular imaging · 2026
    Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Olivia WegrzyniakScience for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Dag Hammarskjölds väg 14C, 3tr, 751 83, Uppsala, Sweden.ORCID http://orcid.org/0000-0001-9636-0390
Francesco LechiScience for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Dag Hammarskjölds väg 14C, 3tr, 751 83, Uppsala, Sweden.
Johanna RokkaScience for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Dag Hammarskjölds väg 14C, 3tr, 751 83, Uppsala, Sweden.
Bogdan MitranScience for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Dag Hammarskjölds väg 14C, 3tr, 751 83, Uppsala, Sweden.
Bo ZhangScience for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Dag Hammarskjölds väg 14C, 3tr, 751 83, Uppsala, Sweden.
Ulrika ThelanderDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
John LöfblomDepartment of Protein Science, Division of Protein Engineering, KTH Royal Institute of Technology, Stockholm, Sweden.
Fredrik Y FrejdDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Olle KorsgrenDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Gaetano PerchiazziHedenstierna Laboratory, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Jonas ErikssonScience for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Dag Hammarskjölds väg 14C, 3tr, 751 83, Uppsala, Sweden.
Olof ErikssonScience for Life Laboratory, Department of Medicinal Chemistry, Uppsala University, Dag Hammarskjölds väg 14C, 3tr, 751 83, Uppsala, Sweden. olof.eriksson@ilk.uu.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLung diseases such as idiopathic pulmonary fibrosis and acute respiratory distress syndrome (ARDS) are associated with significant morbidity and mortality, with limited treatment options. Platelet-derived growth factor receptor beta (PDGFRβ) signaling pathway is a key driver of fibrogenesis in different organs. In the lungs, pericytes have a high PDGFRβ expression, and their role as immune regulators and progenitors of myofibroblasts is increasingly recognized. Non-invasive techniques to assess active lung tissue remodeling are needed to improve disease monitoring and treatment evaluation. This study aimed to evaluate [

results[

conclusionsThis study demonstrated that [

Indexed as

FibrogenesisMolecular imagingPDGFRβPericytesPlatelet-derived growth factor receptor betaPositron emitted tomographyPulmonary fibrosis

Identifiers

PMID40664934
PMCPMC12263540

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.