Evidence map›Paper›PMID 40665010›Full record

ArticleScientific reports2025

Facile synthesis of aminobiphenyl sulfonamides via Chan-Lam coupling and their biological evaluation as potent carbonic anhydrase inhibitors.

Moniba Sharif, Abid Mahmood, Aqsa Kanwal, Matloob Ahmad, Nasir Rasool, Muhammad Usman Qamar, Mohammed H Al Mughram, Amira Ali Mohammed Al-Harethi, Tawaf Ali Shah, Imran Ibrahim Shaikh

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Moniba SharifDepartment of Chemistry, Government College University Faisalabad, Faisalabad, 38000, Pakistan.
Abid MahmoodDepartment of Pharmaceutical Chemistry, Government College University Faisalabad, Faisalabad, 38000, Pakistan.
Aqsa KanwalDepartment of Chemistry, Government College University Faisalabad, Faisalabad, 38000, Pakistan.
Matloob AhmadDepartment of Chemistry, Government College University Faisalabad, Faisalabad, 38000, Pakistan.
Nasir RasoolDepartment of Chemistry, Government College University Faisalabad, Faisalabad, 38000, Pakistan. nasirrasool@gcuf.edu.pk.
Muhammad Usman Qamarinstitute of Microbiology, Faculty of Life Sciences, Government College University, Faisalabad, 38000, Pakistan.
Mohammed H Al MughramDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.
Amira Ali Mohammed Al-HarethiBiological Science Department, Faculty of Science, Sana'a University, Sana'a, P.O 1111, Yemen. amira.alharethi90@gmail.com.
Tawaf Ali ShahCollege of Agriculture Engineering and Food Science, Shandong University of Technology, Zibo, 255000, China.
Imran Ibrahim ShaikhDepartment of pharmacy, Central Laboratory of The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of Lishui University, Lishui People's, Hospital, Lishui, 323000, Zhejiang, China. drorthospine@outlook.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inhibition of carbonic anhydrases (EC 4.2.1.1, hCAs) is known to be a potential target for treatment of several disorders like epilepsy, glaucoma, obesity, and cancer. The current research focuses on the synthesis of a series of 4'-amino-[1,1'-biphenyl]-4-sulfonamide derivatives (9a-e) through cross-coupling reactions in the presence of Cu(OAc)

Indexed as

Carbonic Anhydrase InhibitorsCarbonic AnhydrasesSulfonamidesCarbonic Anhydrase IIHumansMolecular Docking SimulationStructure-Activity RelationshipCarbonic Anhydrase IICarbonic Anhydrase InhibitorsCarbonic AnhydrasesSulfonamidesCA inhibitorsChemical synthesisEnzymes kinetics InhibitionIn Silico studiesSulfonamide derivatives

Identifiers

PMID40665010
PMCPMC12264121

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.