Trial reportBMC oral health2025
Non-surgical periodontal therapy with and without hyaluronic acid gel in type 2 diabetic stage-II periodontitis patients: a randomized clinical trial.
Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05543434 (Evaluation of The Clinical & Radiographic Parameters in Controlled Type 2 Diabetic Patients Treated With Non-Surgical Periodontal Therapy With & Without Using Hyaluronic Acid Gel), which is not on this map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of The Clinical & Radiographic Parameters in Controlled Type 2 Diabetic Patients Treated With Non-Surgical Periodontal Therapy With & Without Using Hyaluronic Acid Gel
Who cites it
2 citing papers in PubMed.
- Hyaluronic Acid and β-Tricalcium Phosphate in Periodontal Pocket Therapy and Alveolar Bone Augmentation: A Systematic Review.Dentistry journal · 2026Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe present trial evaluated clinically and radiographically the effect of topically applied hyaluronic acid (HA) gel in conjunction with professional mechanical plaque removal (PMPR) in type 2 diabetic stage-II periodontitis patients. METHODOLOGY: 26 controlled (HbA1c < 7%) type 2 diabetic stage-II grade B periodontitis patients were included in the current trial and randomly assigned to test (n = 13 patients; PMPR + HA) or control (n = 13; PMPR) groups. At baseline, three- and six-months clinical attachment level (CAL; primary outcome), probing pocket depth (PPD), gingival recession depth (GRD), bleeding on probing (BOP), O'Leary plaque index (PI), HbA1c level, radiographic bone density (RBD) and defect depth (DD; all secondary outcomes) were assessed.
resultsAlthough CAL, PPD, BOP, PI, DD and RBD independently significantly improved in the PMPR + HA and the PMPR groups (p < 0.05), no significant differences were notable between both groups. HbA1c significantly decreased solely in the PMPR + HA group (p < 0.05).
conclusionType 2 diabetic patients with stage-II periodontitis, benefit clinically from PMPR in the presence or absence of adjunctive HA gel application. Interestingly, HA as an adjunct to PMPR significantly improved HbA1c levels in controlled type 2 diabetic stage-II periodontitis patients.
trial registrationThe study was registered in the US National Institutes of Health Clinical Trials Registry (NCT05543434) in September 2022.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.