Evidence map›Paper›PMID 40665379›Full record

ReviewJournal of orthopaedic surgery and research2025

Stem cell-derived exosomes: a potential therapeutic strategy for enhancing tendon stem/progenitor cells function in tendon-bone healing.

Junjie Tang, Peng Shen, Xinyuan Wu, Minhao Chen, Hua Xu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Junjie Tang *Department of Orthopaedics, Medical School of Nantong University, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Peng Shen *Department of Orthopaedics, Medical School of Nantong University, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Xinyuan Wu *Department of Orthopaedics, Medical School of Nantong University, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Minhao ChenDepartment of Orthopaedics, Medical School of Nantong University, Affiliated Hospital of Nantong University, Nantong, 226001, China. chenminhao_nt@126.com.
Hua XuDepartment of Orthopaedics, Medical School of Nantong University, Affiliated Hospital of Nantong University, Nantong, 226001, China. xuhuantu@yeah.net.

Funding

China Postdoctoral Science Foundation 2022M711718Jiangsu Provincial Research Hospital YJXYY202204Natural Science Foundation of Nantong JC2023098Scientific Research Project of Nantong Commission of Health MS2023022
6 · The paper itself

Abstract

Tendon-bone insertion (TBI) injuries and diseases are one of the common musculoskeletal conditions that can severely impair an individual's daily activities and quality of life. The healing process following an injury is intricate and depending on microenvironmental factors such as mechanical loading, inflammatory responses, and the extracellular matrix. Tendon stem/progenitor cells (TSPCs) primarily contribute to the replenishment of tendon cells via self-renewal and differentiation, which is essential for tendon-bone healing. Exosomes, small extracellular vesicles from various cell types, have attracted significant interest for their potential in regenerative medicine, particularly for treating tendon disorders. Recent studies indicate that exosomes from various cell sources, including mesenchymal stem cells (MSCs) and adipose-derived stem cells (ADSCs), can effectively modulating the activity of TSPCs and enhance their therapeutic potential. This review provides an overview of the mechanisms and functions of stem cell-derived exosomes in altering the properties of TSPCs and facilitating tendon-bone healing. In conclusion, exosomes offer a promising therapeutic approach for TBI injuries. However, further clinical validation is required. Utilizing the regenerative capabilities of exosomes could address promotion of tendon-bone healing and enhance the quality of life for affected patients.

Indexed as

Bone and BonesExosomesStem CellsStem Cell TransplantationTendon InjuriesTendonsWound HealingAnimalsHumansMesenchymal Stem CellsExosomesTendon-bone healingTendon-bone insertion injuresTendon stem/progenitor cells

Identifiers

PMID40665379
PMCPMC12265259

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.