ArticleMedical physics2025
Commissioning of a 142.4 MeV ultra-high dose rate (UHDR) proton beamline in a synchrotron-based proton therapy system.
Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Expanding dose and dose-rate capabilities of a synchrotron-based pre-clinical proton FLASH irradiation platform.Medical physics · 2026Article
- 3D Imaging of Proton FLASH Radiation Using a Multi-Detector Small Animal PET System.Tomography (Ann Arbor, Mich.) · 2025Article
- Commissioning of a 142.4 MeV ultra-high dose rate (UHDR) proton beamline in a synchrotron-based proton therapy system.Medical physics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundRecent studies suggest that radiotherapy at ultrahigh dose rates (>40 Gy/s, FLASH) offers normal tissue sparing effects while maintaining tumor control. There is significant interest in preclinical studies investigating the mechanism of FLASH sparing effects. PURPOSE: This study aims to commission a fixed proton beamline within a synchrotron-based proton therapy system for preclinical proton FLASH research.
methodsModifications were made to the Hitachi PROBEAT-CR synchrotron system to enhance RF extraction power and increase proton beam current at 142.4 MeV. A high-speed electrometer and an optimized transmission ion chamber (IC) were implemented for ultra-high dose rate (UHDR) beam monitoring and delivery, replacing the conventional beam monitoring IC. Beam output was measured using a Faraday cup in both UHDR and clinical modes. Gafchromic film measurements and Monte Carlo simulations were employed to validate dose delivery in a solid water phantom with various spot scanning patterns.
resultsThe calibration of transmission IC against Faraday cup shows sufficient charge collection efficiency at both clinical dose rates and UHDR. The UHDR PBS beamline demonstrates better than 1% reproducibility and linearity in the absolute beam output. Due to the limited charge per spill, the delivered dose per spill is inversely proportional to the field size. However, the system can deliver up to 41.4 Gy (268.1 Gy/sec) at 2 cm depth with a field size (FWHM) of 8.2 mm, demonstrating suitability for small animal proton FLASH irradiation studies.
conclusionWe successfully commissioned a fixed beam proton UHDR PBS beamline in a synchrotron-based proton therapy system. Despite synchrotron-specific system constraints, our system enables controlled UHDR delivery for preclinical proton FLASH research.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.