Evidence mapPaperPMID 40665933Full record

ReviewAdvanced materials (Deerfield Beach, Fla.)2025

Biomimetic Cell Membrane-Coated Scaffolds for Enhanced Tissue Regeneration.

Carmen Alvarez-Lorenzo, Alejandro Ramirez-Romero, Diana Peixoto, Maria Vivero-Lopez, Isabel Rodríguez-Moldes, Angel Concheiro

Abstract readReview
In one paragraph

Review in Advanced materials (Deerfield Beach, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Biocompatible Thin Films Deposited by Laser Techniques.Materials (Basel, Switzerland) · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Biomimetic Cell Membrane-Coated Scaffolds for Enhanced Tissue Regeneration.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carmen Alvarez-LorenzoDepartamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, 15782, Spain.ORCID https://orcid.org/0000-0002-8546-7085
Alejandro Ramirez-RomeroDepartamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, 15782, Spain.ORCID https://orcid.org/0009-0006-2042-6211
Diana PeixotoDepartamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, 15782, Spain.ORCID https://orcid.org/0000-0001-9772-4504
Maria Vivero-LopezDepartamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, 15782, Spain.ORCID https://orcid.org/0000-0002-7438-6458
Isabel Rodríguez-MoldesGrupo NEURODEVO, Departamento de Bioloxía Funcional, Universidade de Santiago de Compostela, Santiago de Compostela, 15782, Spain.ORCID https://orcid.org/0000-0003-1460-5935
Angel ConcheiroDepartamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma (GI-1645), Facultad de Farmacia, Instituto de Materiales (iMATUS) and Health Research Institute of Santiago de Compostela (IDIS), Universidade de Santiago de Compostela, Santiago de Compostela, 15782, Spain.ORCID https://orcid.org/0000-0003-0507-049X

Funding

European Regional Development Fund ED431C 2024/09Ministerio de Ciencia, Innovación y Universidades PID2023-150422OB-I00Xunta de Galicia ED431C 2024/09
6 · The paper itself

Abstract

Cell membranes are emerging as valuable models for regulating scaffold-cell interactions in tissue engineering. Their unique structure and function provide an ideal template for creating biomimetic surfaces that support cell adhesion, proliferation, and differentiation. This has led to the development of cell membrane-coated scaffolds (CMCSs), a new class of biomaterials designed to mimic native cellular interfaces and improve therapeutic outcomes. This review begins with an overview of cell-extracellular matrix (ECM) interactions, highlighting their key roles in tissue remodeling and healing. It then introduces ECM-inspired coatings before focusing on CMCSs. A detailed analysis of scaffolds coated with specific membrane components or entire cell membranes is presented, with applications in skin and wound healing, bone regeneration, neural repair, and vascular grafts. Techniques for membrane extraction, surface functionalization, and preservation of membrane integrity and orientation are analyzed. CMCSs demonstrate advantages over traditional scaffolds, including improved homotypic cell attraction, immune modulation, and resistance to non-specific protein and bacterial adhesion. However, several challenges persist, such as standardizing membrane isolation methods, optimizing coating density, and evaluating the stability and reproducibility of coatings, especially when using hybrid membranes from multiple cell types. Overcoming these barriers could significantly advance scaffold technologies for regenerative medicine.

Indexed as

Biomimetic MaterialsCell MembraneCoated Materials, BiocompatibleRegenerationTissue EngineeringTissue ScaffoldsAnimalsExtracellular MatrixHumansRegenerative MedicineCoated Materials, Biocompatiblebioinspired zwitterionizationbone regenerationcell membrane coatingglycosylationregenerative medicinescaffoldwound healing

Identifiers

PMID40665933
PMCPMC12510297

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.