Evidence map›Paper›PMID 40666307›Full record

ArticleAdvances in neurotoxicology2025

Role of glial cells in neurotoxicological effects of alcohol.

Yousef Tizabi, Bruk Getachew, Michael Aschner, Michael A Collins

Abstract read
In one paragraph

Article in Advances in neurotoxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yousef TizabiDepartment of Pharmacology, Howard University College of Medicine, Washington, DC, United States.
Bruk GetachewDepartment of Pharmacology, Howard University College of Medicine, Washington, DC, United States.
Michael AschnerDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, United States.
Michael A CollinsAlcohol Research Program, Loyola University Chicago, Maywood, IL, United States.

Funding

Mechanisms of Manganese NeurotoxicityR01ES010563 · NIEHS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Michael Aschner, Aaron B Bowman · 2001 to 2026
$11.9M
Mechanisms of Methylmercury Induced Neuron ToxicityR01ES007331 · NIEHS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Michael Aschner, Aaron B Bowman · 1996 to 2026
$10.6M
Binge alcohol-induced neurodegeneration and omega-3 DHA ProtectionU01AA018279 · NIAAA · LOYOLA UNIVERSITY CHICAGO · PI COLLINS, MICHAEL A. · 2009 to 2018
$2.7M
Novel Interventions in Alcohol Induced DepressionR03AA022479 · NIAAA · HOWARD UNIVERSITY · PI TIZABI, YOUSEF · 2014 to 2015
$149k
NIAAA NIH HHS R03 AA022479NIAAA NIH HHS U01 AA018279NIEHS NIH HHS R01 ES007331NIEHS NIH HHS R01 ES010563
6 · The paper itself

Abstract

Alcohol (ethanol), presumably consumed as wine as far back as 7000 BC, is most likely the first addictive substance known to man. In modern days, its abuse leading to neurotoxicity and a myriad of organ damages, is of considerable social and medical concern. In the United States alone, approximately 180,000 people die yearly because of alcohol-related accidents and diseases. Given its ubiquitous nature, alcohol may interact with many cellular components. In this chapter, we specifically concentrate on its neurotoxic mechanisms involving glial cells and their role in neuroinflammation. Moreover, exploitation of this knowledge for potential novel interventions in alcohol-induced neurotoxicity are touched upon.

Identifiers

PMID40666307
PMCPMC12261501

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.