Evidence map›Paper›PMID 40666556›Full record

ArticleCureus2025

Adult-Onset Still's Disease Associated With Hyperimmunoglobulin-E: A Case Report.

Parishad Yakhchalian, Mahwish Sheikh, Mohammed G Elhassan

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Parishad YakhchalianInternal Medicine, Saint Agnes Medical Center, Fresno, USA.
Mahwish SheikhInternal Medicine, Saint Agnes Medical Center, Fresno, USA.
Mohammed G ElhassanInternal Medicine, Saint Agnes Medical Center, Fresno, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adult-onset Still's disease (AOSD) is a rare, chronic, multisystem inflammatory disorder of unknown etiology. Diagnosis is made clinically and can be challenging. AOSD typically affects young adults but can occur in older patients. The association between AOSD and very high immunoglobulin-E levels (also known as hyperimmunoglobulin-E) is not well studied. In this report, we present the case of a middle-aged woman with AOSD who presented with more than two weeks of fever, severe generalized weakness, and sore throat, and responded very well to prednisone. She was found to have hyperimmunoglobulin-E without a history of allergic disease or parasitic infection.

Indexed as

adult-onset still's diseaseaosdautoimmune diseasehyperimmunoglobulinquotidian fever

Identifiers

PMID40666556
PMCPMC12262155

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.