ArticleHealth science reports2025
HIV and Maternal-Fetal Immunity: Challenges and Strategies for Reducing Vertical Transmission-A Narrative Review.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- HIV positivity rate, mother-to-child transmission and associated factors among HIV exposed infants in Western Ethiopia: a cross-sectional study.BMC pediatrics · 2026Article
- Trends and inequalities in HIV testing uptake among pregnant women during antenatal care in Ghana: a decomposition analysis from 2008 to 2022.Tropical medicine and health · 2026Article
- Translational insights into manufacturability and stability of broadly neutralizing antibodies for pediatric HIV prevention: lessons from plant-produced CAP256-VRC26.25.Frontiers in pediatrics · 2026Article
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Authors and funding
1 author.
Funding
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Abstract
Background and Aims: Mother-to-child transmission (MTCT) of HIV remains a significant global health challenge, particularly in resource-limited settings. The virus disrupts maternal-fetal immunity through immune dysregulation, placental barrier impairment, and altered antibody transfer, thereby increasing the risk of vertical transmission. Methods and Results: This narrative review synthesizes current evidence on the immunological and clinical factors influencing MTCT. It highlights how maternal immune exhaustion, placental inflammation, and suboptimal ART timing contribute to transmission. While widespread use of ART has reduced MTCT rates, persistent challenges include late ART initiation, HIV drug resistance, co-infections, and transmission through breastfeeding. Emerging strategies-such as maternal immune modulation, monoclonal antibody therapies, and tailored ART regimens-show potential for further risk reduction. Conclusion: To effectively minimize MTCT, comprehensive prevention approaches are essential. These should combine medical interventions with maternal nutrition support, co-infection management, and safe breastfeeding practices under ART coverage. A multifaceted strategy is key to protecting both maternal and infant health.
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Registered trials
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