Evidence map›Paper›PMID 40667039›Full record

ArticlebioRxiv : the preprint server for biology2025

Inhibition of nonsense-mediated decay in TDP-43 deficient neurons reveals novel cryptic exons.

Irika R Sinha, Yingzhi Ye, Yini Li, Parker S Sandal, Philip C Wong, Shuying Sun, Jonathan P Ling

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Irika R SinhaDepartments of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-6440-7019
Yingzhi YePhysiology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-7380-6529
Yini LiPathology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-2213-0650
Parker S SandalPathology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0009-0006-4452-2400
Philip C WongDepartments of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0001-8162-3274
Shuying SunDepartments of Neuroscience, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0002-8449-7370
Jonathan P LingPathology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.ORCID 0000-0003-1927-9729

Funding

Single molecule study of C9ORF72 repeat RNA metabolisms in ALS/FTDRF1NS113820 · JOHNS HOPKINS UNIVERSITY · 2025 to 2025
$3.1M
Regulation mechanism and functional genomics of LINE1 RNA in TDP-43 linked neurodegenerationR01AG078948 · JOHNS HOPKINS UNIVERSITY · 2025 to 2025
$807k
The role of m6A RNA methylation in C9ORF72-ALS/FTDR01NS127925 · JOHNS HOPKINS UNIVERSITY · 2025 to 2025
$583k
FDA HHS U01 FD008129NIA NIH HHS R01 AG078948NINDS NIH HHS R01 NS127925NINDS NIH HHS RF1 NS095969NINDS NIH HHS RF1 NS113820NINDS NIH HHS RF1 NS129878
6 · The paper itself

Abstract

TAR DNA-binding protein 43 kDa (TDP-43) is an essential splicing repressor whose loss of function underlies the pathophysiology of amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD). Nuclear clearance of TDP-43 disrupts its function and leads to the inclusion of aberrant cryptic exons. These cryptic exons frequently introduce premature termination codons resulting in the degradation of affected transcripts through nonsense-mediated mRNA decay (NMD). Conventional RNA sequencing approaches thus may fail to detect cryptic exons that are efficiently degraded by NMD, precluding identification of potential therapeutic targets. We generated a comprehensive set of neuronal targets of TDP-43 in human iPSC-derived i

Identifiers

PMID40667039
PMCPMC12262666

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.