Evidence map›Paper›PMID 40667072›Full record

ArticlebioRxiv : the preprint server for biology2025

Cholinergic modulation of dopamine release drives effortful behavior.

Gavin C Touponse, Matthew B Pomrenze, Teema Yassine, Viraj Mehta, Nicholas Denomme, Zihui Zhang, Robert C Malenka, Neir Eshel

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Gavin C TouponseDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305.ORCID 0000-0001-8087-3351
Matthew B PomrenzeNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305.ORCID 0000-0002-9032-5911
Teema YassineDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305.ORCID 0009-0001-2577-6054
Viraj MehtaDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305.ORCID 0009-0005-5469-6490
Nicholas DenommeNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305.ORCID 0000-0002-7631-0385
Zihui ZhangDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305.ORCID 0000-0001-8002-9396
Robert C MalenkaNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305.ORCID 0000-0002-5428-5211
Neir EshelDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA 94305.ORCID 0000-0002-5976-2013

Funding

Training CoreP50DA042012 · NIDA · STANFORD UNIVERSITY · PI Karl A. Deisseroth · 2017 to 2026
$27.1M
Neural circuits of frustrationK08MH123791 · NIMH · STANFORD UNIVERSITY · PI ESHEL, NEIR · 2020 to 2024
$1.2M
Modulation of protracted opioid withdrawal by dorsal raphe dynorphin neuronsK99DA056573 · NIDA · STANFORD UNIVERSITY · PI POMRENZE, MATTHEW B · 2022 to 2023
$317k
NIDA NIH HHS K99 DA056573NIDA NIH HHS P50 DA042012NIMH NIH HHS K08 MH123791
6 · The paper itself

Abstract

Effort is costly: given a choice, we tend to avoid it

Identifiers

PMID40667072
PMCPMC12262595

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.