Evidence map›Paper›PMID 40667126›Full record

ArticlebioRxiv : the preprint server for biology2025

Functional Inputs to the Subgenual Cingulate Cortex Distinguish Neurotypical Individuals with Severe and Mild Depressive Problems: Granger Causality and Clustering Analyses.

Huey-Ting Li, Yu Chen, Shefali Chaudhary, Jaime S Ide, Chiang-Shan R Li

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Huey-Ting LiYale College, New Haven, CT 06511, U.S.A.
Yu ChenDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06520, U.S.A.ORCID 0000-0003-4946-4693
Shefali ChaudharyDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06520, U.S.A.
Jaime S IdeDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06520, U.S.A.
Chiang-Shan R LiDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT 06520, U.S.A.

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
Noradrenergic mechanisms of alcohol's impact on the development of MCI and early stage ADR01AG072893 · NIA · YALE UNIVERSITY · PI LI, CHIANG-SHAN RAY · 2020 to 2024
$1.8M
Multi-level statistical classification of substance use disorderR01DA051922 · NIDA · UNIVERSITY OF CONNECTICUT STORRS · PI BI, JINBO, LI, CHIANG-SHAN RAY · 2020 to 2023
$1.8M
NIA NIH HHS R01 AG072893NIDA NIH HHS R01 DA051922NIMH NIH HHS U54 MH091657
6 · The paper itself

Abstract

Extant research has implicated functional connectivity of the subgenual anterior cingulate cortex (sgACC) in major depressive disorders or depressive traits in neurotypical populations. However, prior studies have not distinguished the inputs and outputs of the sgACC, and the "diagnostic" accuracy of these connectivity metrics remains elusive. Here, we analyzed data of 890 subjects (459 women, age 22 to 35) from the Human Connectome Project using Granger causality analyses (GCA) with the sgACC as the seed and 268 regions of interest from the Shen's atlas as targets. Individual connectivities were assessed with an

Indexed as

anxietydepressionfunctional connectivityGranger causalitymachine learningsubgenual cingulate

Identifiers

PMID40667126
PMCPMC12262191

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.