Evidence map›Paper›PMID 40667153›Full record

ArticlebioRxiv : the preprint server for biology2025

Oxygen uptake in human donor corneas: the centripetal gradient and its changes in culture and correlation with wounds and aminophylline treatment.

Ana M Sandoval-Castellanos, Jeevan Mann, Brian Reid, Jennifer Y Li, Mark J Mannis, Min Zhao

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ana M Sandoval-CastellanosDepartment of Ophthalmology & Vision Science, Institute for Regenerative Cures, School of Medicine, University of California, Davis. Davis, California, USA.ORCID 0000-0002-6557-5505
Jeevan MannDepartment of Ophthalmology & Vision Science, Institute for Regenerative Cures, School of Medicine, University of California, Davis. Davis, California, USA.ORCID 0009-0002-6769-9461
Brian ReidDepartment of Ophthalmology & Vision Science, Institute for Regenerative Cures, School of Medicine, University of California, Davis. Davis, California, USA.
Jennifer Y LiDepartment of Ophthalmology & Vision Science, Institute for Regenerative Cures, School of Medicine, University of California, Davis. Davis, California, USA.
Mark J MannisDepartment of Ophthalmology & Vision Science, Institute for Regenerative Cures, School of Medicine, University of California, Davis. Davis, California, USA.
Min ZhaoDepartment of Ophthalmology & Vision Science, Institute for Regenerative Cures, School of Medicine, University of California, Davis. Davis, California, USA.ORCID 0000-0002-2500-3035

Funding

VISION RESEARCH CORE GRANTP30EY012576 · NEI · UNIVERSITY OF CALIFORNIA DAVIS · PI W MARTIN USREY · 1999 to 2026
$18.9M
Molecular Generators at Corneal Wounds Produce and regulate the Wound Electrical SignalsR01EY019101 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ZHAO, MIN · 2010 to 2023
$5.2M
NEI NIH HHS P30 EY012576NEI NIH HHS R01 EY019101
6 · The paper itself

Abstract

Oxygen is a diatomic element abundant in the atmosphere and is essential for homeostatic and metabolic processes within the cornea. The avascular cornea uptakes oxygen from the atmosphere and performs refractory and protective functions that are essential for eyesight. However, the spatial-temporal profile of oxygen uptake (O

Indexed as

corneamesoscopic metabolism heterogeneityoxygen uptakespatiotemporal profilewound healing

Identifiers

PMID40667153
PMCPMC12262431

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.