Evidence map›Paper›PMID 40667239›Full record

ArticlebioRxiv : the preprint server for biology2025

The Luminal Ring Protein C2CD3 Acts as a Radial In-to-Out Organizer of the Distal Centriole and Appendages.

Eloïse Bertiaux, Vincent Louvel, Caitlyn L McCafferty, Hugo van den Hoek, Umut Batman, Souradip Mukherjee, Lorène Bournonville, Olivier Mercey, Isabelle Mean, Adrian Müller and 8 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Eloïse BertiauxUniversity of Geneva, Department of Molecular and Cellular Biology, Sciences III, Geneva, Switzerland.
Vincent LouvelUniversity of Geneva, Department of Molecular and Cellular Biology, Sciences III, Geneva, Switzerland.
Caitlyn L McCaffertyBiozentrum, University of Basel, Basel, Switzerland.
Hugo van den HoekBiozentrum, University of Basel, Basel, Switzerland.
Umut BatmanUniversity of Geneva, Department of Molecular and Cellular Biology, Sciences III, Geneva, Switzerland.
Souradip MukherjeeUniversity of Geneva, Department of Molecular and Cellular Biology, Sciences III, Geneva, Switzerland.
Lorène BournonvilleUniversity of Geneva, Department of Molecular and Cellular Biology, Sciences III, Geneva, Switzerland.ORCID 0000-0002-2806-4802
Olivier MerceyUniversity of Geneva, Department of Molecular and Cellular Biology, Sciences III, Geneva, Switzerland.
Isabelle MeanUniversity of Geneva, Department of Molecular and Cellular Biology, Sciences III, Geneva, Switzerland.
Adrian MüllerBiozentrum, University of Basel, Basel, Switzerland.
Philippe Van der StappenBiozentrum, University of Basel, Basel, Switzerland.
Garrison BussDepartment of Biology, Stanford University, Stanford, USA.
Jean DaraspeElectron Microscopy Facility, Biophore, University of Lausanne, Lausanne, Switzerland.
Christel GenoudElectron Microscopy Facility, Biophore, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-0933-9911
Tim StearnsDepartment of Biology, Stanford University, Stanford, USA.
Benjamin D EngelBiozentrum, University of Basel, Basel, Switzerland.ORCID 0000-0002-0941-4387
Virginie HamelUniversity of Geneva, Department of Molecular and Cellular Biology, Sciences III, Geneva, Switzerland.ORCID 0000-0001-5092-2343
Paul GuichardUniversity of Geneva, Department of Molecular and Cellular Biology, Sciences III, Geneva, Switzerland.ORCID 0000-0002-0363-1049

Funding

Structure and mechanism of the centrosome-cilium complexR35GM130286 · NIGMS · STANFORD UNIVERSITY · PI STEARNS, TIM · 2019 to 2023
$3.4M
NIGMS NIH HHS R35 GM130286
6 · The paper itself

Abstract

Centrioles are polarized microtubule-based structures with appendages at their distal end that are essential for cilia formation and function. The protein C2CD3 is critical for distal appendage assembly, with mutations linked to orofaciodigital syndrome and other ciliopathies. However, its precise molecular role in appendage recruitment remains unclear. Using Ultrastructure Expansion Microscopy (U-ExM), iterative U-ExM, and

Indexed as

appendagesC2CD3centrioleexpansion microscopyin situ cryo-ETluminal distal ring

Identifiers

PMID40667239
PMCPMC12262607

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.