Evidence map›Paper›PMID 40667247›Full record

ArticlebioRxiv : the preprint server for biology2025

Inhibition of De Novo Autoantibody Production Attenuates Chronic Antibody-Mediated Rejection of Kidney Allografts Despite Maintenance of High Donor-Specific Antibody Titers.

Yosuke Mitsui, Karen S Keslar, Michael Nicosia, Danielle D Kish, Nina Dvorina, Chengsong Zhu, Mitchell A Olman, Brian D Southern, William M Baldwin, Robert L Fairchild

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yosuke MitsuiDepartment of Inflammation & Immunity, Cleveland Clinic Research, Cleveland, OH 44195.ORCID 0000-0002-8598-0823
Karen S KeslarDepartment of Inflammation & Immunity, Cleveland Clinic Research, Cleveland, OH 44195.ORCID 0000-0001-8609-4797
Michael NicosiaDepartment of Inflammation & Immunity, Cleveland Clinic Research, Cleveland, OH 44195.ORCID 0000-0003-2295-0763
Danielle D KishDepartment of Inflammation & Immunity, Cleveland Clinic Research, Cleveland, OH 44195.ORCID 0009-0000-0121-229X
Nina DvorinaDepartment of Inflammation & Immunity, Cleveland Clinic Research, Cleveland, OH 44195.ORCID 0000-0002-0352-6636
Chengsong ZhuUniversity of Texas Southwestern Medical Center Autoantibody Profiling Service, Austin, TX 75235.ORCID 0000-0001-8872-9450
Mitchell A OlmanDepartment of Inflammation & Immunity, Cleveland Clinic Research, Cleveland, OH 44195.ORCID 0000-0003-3262-3598
Brian D SouthernDepartment of Inflammation & Immunity, Cleveland Clinic Research, Cleveland, OH 44195.ORCID 0000-0003-2983-5741
William M BaldwinDepartment of Inflammation & Immunity, Cleveland Clinic Research, Cleveland, OH 44195.ORCID 0000-0002-7271-1827
Robert L FairchildDepartment of Inflammation & Immunity, Cleveland Clinic Research, Cleveland, OH 44195.

Funding

Chronic Antibody-Mediated Rejection of Kidney AllograftsR01AI167939 · NIAID · CLEVELAND CLINIC LERNER COM-CWRU · PI Robert L Fairchild · 2022 to 2026
$3.2M
Acute Antibody Mediated Kidney Allograft RejectionR01AI158421 · NIAID · CLEVELAND CLINIC LERNER COM-CWRU · PI FAIRCHILD, ROBERT L · 2021 to 2025
$3.0M
Profibrotic Mechanisms of the TRPV4-PI3K-gamma Protein ComplexR01HL158746 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI OLMAN, MITCHELL ALAN · 2021 to 2024
$1.6M
NHLBI NIH HHS R01 HL158746NIAID NIH HHS R01 AI158421NIAID NIH HHS R01 AI167939
6 · The paper itself

Abstract

Acute and chronic antibody mediated rejection (ABMR) continues to decrease clinical kidney graft function and survival. Dysregulated donor-specific antibody (DSA) responses are induced in B6.CCR5

Identifiers

PMID40667247
PMCPMC12262401

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.