Evidence map›Paper›PMID 40667338›Full record

ArticlebioRxiv : the preprint server for biology2025

Donor Age Impairs Vasculogenic Potential of hiPSC-Derived Endothelial Progenitors.

Bryce Larsen, Cody Callahan, Arshitha Rayanki, Sara Faulkner, Janet Zoldan

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bryce LarsenDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78751, USA.ORCID 0000-0003-4051-8907
Cody CallahanDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78751, USA.
Arshitha RayankiDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78751, USA.
Sara FaulknerDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78751, USA.
Janet ZoldanDepartment of Biomedical Engineering, The University of Texas at Austin, Austin, TX 78751, USA.

Funding

Investigating the impact of donor and environmental age on iPSC derived endothelial progenitorsF31HL176136 · UNIVERSITY OF TEXAS AT AUSTIN · 2025 to 2025
$44k
NHLBI NIH HHS F31 HL176136
6 · The paper itself

Abstract

Background: Human induced pluripotent stem cells (hiPSCs) hold promise for vascular regeneration, but preliminary research often relies on neonatal donors, whereas clinical applications will use cells derived from older adults. Although the impact of donor age on reprogramming efficiency has been studied, its effect on the functionality of hiPSC-derived endothelial progenitors (hiPSC-EPs) remains unclear. This question is the focus of the current study. Methods and Results: We derived EPs from iPSCs sourced from three neonatal donors (ND) and three mature donors (MD) matched 1:1 for sex and somatic cell origin. We assessed their functional, epigenetic, and transcriptomic characteristics. Despite higher CD34 Conclusions: Donor age significantly alters the vasculogenic function of hiPSC-EPs. These findings underscore the necessity of donor-specific considerations in hiPSC-based vascular engineering and highlight potential barriers to translating hiPSC-derived therapeutics into older patient populations.

Identifiers

PMID40667338
PMCPMC12262358

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.