Evidence map›Paper›PMID 40667352›Full record

ArticlebioRxiv : the preprint server for biology2025

Ablation of

Mascha Koenen, Tobias Becher, Giulia Pagano, Ilaria Del Gaudio, Jorge A Barrero, Augusto C Montezano, Jenelys Ruiz Ortiz, Zeran Lin, Nicolás Gómez-Banoy, Rose Amblard and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Mascha KoenenLaboratory of Molecular Metabolism, The Rockefeller University; New York, NY, 10065, USA.ORCID 0000-0002-1024-4506
Tobias BecherLaboratory of Molecular Metabolism, The Rockefeller University; New York, NY, 10065, USA.
Giulia PaganoLaboratory of Molecular Metabolism, The Rockefeller University; New York, NY, 10065, USA.
Ilaria Del GaudioDepartment of Pathology and Laboratory Medicine, Cardiovascular Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine; New York, NY, 10065, USA.
Jorge A BarreroLaboratory of Molecular Metabolism, The Rockefeller University; New York, NY, 10065, USA.
Augusto C MontezanoResearch Institute of the McGill University Health Centre; Montreal, Quebec, H4A 3J1, Canada.ORCID 0000-0002-8658-7994
Jenelys Ruiz OrtizBioinformatics Resource Center, The Rockefeller University; New York, NY, 10065, USA.
Zeran LinLaboratory of Molecular Metabolism, The Rockefeller University; New York, NY, 10065, USA.ORCID 0000-0003-4418-2443
Nicolás Gómez-BanoyLaboratory of Molecular Metabolism, The Rockefeller University; New York, NY, 10065, USA.ORCID 0000-0002-3552-1768
Rose AmblardLaboratory of Molecular Metabolism, The Rockefeller University; New York, NY, 10065, USA.
Meltem E KarsThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai; New York, NY, 10029, USA.ORCID 0000-0001-5922-5608
Luisa RubinelliDepartment of Pathology and Laboratory Medicine, Cardiovascular Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine; New York, NY, 10065, USA.
Sarah J HalixLaboratory of Molecular Metabolism, The Rockefeller University; New York, NY, 10065, USA.
Zhen Fang Huang CaoLaboratory of Molecular Metabolism, The Rockefeller University; New York, NY, 10065, USA.
Xing ZengDepartment of Physiology, UT Southwestern; Dallas, TX, 75390, USA.
Scott D ButlerDepartment of Biomedical Sciences, College of Veterinary Medicine, Cornell University, Ithaca; NY, 14853, USA.
Yuval ItanThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai; New York, NY, 10029, USA.
Rhian M TouyzResearch Institute of the McGill University Health Centre; Montreal, Quebec, H4A 3J1, Canada.ORCID 0000-0003-0670-0887
Annarita Di LorenzoDepartment of Pathology and Laboratory Medicine, Cardiovascular Research Institute, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine; New York, NY, 10065, USA.ORCID 0000-0003-1239-4222
Paul CohenLaboratory of Molecular Metabolism, The Rockefeller University; New York, NY, 10065, USA.ORCID 0000-0002-2786-8585

Funding

Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · 2025 to 2025
$9.2M
Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · ROCKEFELLER UNIVERSITY · 2025 to 2025
$3.7M
SPHINGOLIPID BIOLOGY OF MACROPHAGE IN CORONARY ATHEROSCLEROSIS DEVELOPMENT AND PROGRESSIONR01HL152195 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Annarita Di Lorenzo · 2022 to 2024
$1.8M
An Encyclopedia of the Adipose Tissue Secretome to Identify Mediators of Health and DiseaseRC2DK129961 · ROCKEFELLER UNIVERSITY · 2025 to 2025
$1.7M
NCATS NIH HHS UL1 TR001866NCATS NIH HHS UL1 TR004419NHLBI NIH HHS R01 HL152195NIDDK NIH HHS RC2 DK129961
6 · The paper itself

Abstract

While excess adiposity is a major risk factor for hypertension and cardiovascular disease, brown fat is associated with protection from these pathologies. Whether brown fat has a causal role in this process and the underlying molecular mechanisms remain unknown. Here we investigate the role of murine beige fat, as a model of inducible brown fat in humans, in adipocyte-vascular crosstalk. Using mice with an adipocyte-specific deletion of PRDM16, resulting in a loss of beige adipocyte identity, we discover a dramatic remodeling of perivascular adipose tissue, increased vascular reactivity and elevated blood pressure. We further show that the circulating enzyme

Identifiers

PMID40667352
PMCPMC12262805

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.