ArticleFrontiers in nutrition2025
Association between triglyceride glucose-waist-adjusted waist index and incident stroke in Chinese adults: a prospective cohort study.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Association between insulin resistance surrogate markers and cardiovascular disease risk in individuals with subclinical metabolic disorders: a prospective cohort study based on baseline levels, cumulative exposure, and longitudinal trajectories.Cardiovascular diabetology · 2026Article
- Simplicity meets accuracy: TyG-Waist as a practical alternative to CVAI for type 2 diabetes prediction in high-risk Chinese adults.BMC endocrine disorders · 2026Article
- Comparison of the predictive power of novel insulin resistance, lipid metabolism and obesity indices for the risk of developing dyslipidaemia in adults.BMC endocrine disorders · 2026Article
- Integrative Assessment of TyG Index, FIB-4, and eGFR as Composite Predictors of Metabolic Risk Clusters in Adults.Metabolites · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Current literature lacks evidence on the association between the triglyceride glucose-weight-adjusted waist index (TyG-WWI) and incident stroke. Therefore, this study aims to elucidate the relationship between TyG-WWI and stroke risk in a nationally representative cohort of middle-aged and elderly Chinese adults by: (1) Quantitatively assessing its prospective association with incident stroke, and (2) Investigating potential nonlinear relationships and inflection points. Methods: This national longitudinal study examined data from five waves of the CHARLS (2011-2020). TyG-WWI served as the key exposure variable, while stroke incidence, as determined by physician diagnosis, was the principal outcome of interest. Associations were evaluated using Cox proportional hazards models alongside nonlinear analyses, with careful adjustment for a range of covariates. To further ensure the reliability of our findings, we performed a series of sensitivity and subgroup analyses. Results: In this study, we investigated the association between TyG-WWI and stroke risk. The results demonstrated a significant positive correlation between TyG-WWI quartiles and stroke risk, with HRs of 1.35 (95% CI 1.08-1.69, Conclusion: In conclusion, our study reveals a significant association between TyG-WWI and stroke risk in the middle-aged and elderly population in China, with stroke risk increasing progressively across higher TyG-WWI quartiles. Notably, this association was significantly more pronounced in non-hypertensive individuals. Furthermore, an inflection point indicates a stronger association beyond this threshold.
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