ArticleFrontiers in toxicology2025
Tributyl phosphate as a type of environmental endocrine disruptor associated with liver fibrosis: insights from NHANES and
Article in Frontiers in toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Environmental endocrine disruptors (EEDs) had been proved as significant risk factors for liver fibrosis. However, which specific pollutants predominantly related to liver fibrosis remain unidentified. This study was aimed to screen in the specific EEDs using NHANES data and further validate the findings in BRL-3A hepatocytes. Methods: A total of 5,843 adult participants (≥18 years) incorporating data on EEDs/metabolites, demographics, lifestyle factors, and vibration-controlled transient elastography (VCTE) measurements were gated from the NHANES. Advanced analytical methods including LASSO regression, multivariable logistic regression, and restricted cubic spline (RCS) modeling were implemented for pollutant screening. Results: Di-n-butyl phthalate (DBuP), the metabolites of tributyl phosphate (TBP), was demonstrated to be the strongest EEDs associated with liver fibrosis ( Conclusion: Our findings establish TBP as a novel environmental determinant positively correlated with liver fibrosis in U.S. adults. The profibrotic effects appear mediated through transcriptional activation of extracellular matrix remodeling genes, particularly via MMP9 pathway modulation.
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