Evidence map›Paper›PMID 40667541›Full record

ArticleAmerican journal of cancer research2025

METTL3-mediated m

Cheng Chen, Jun Li, Bingwu Yang, Li Kong, Di Zhang, Jianran Guo, Longxun Zhou, Guangliang Bai, Huaqiang Zhao, Zhen Meng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cheng ChenShandong Provincial Key Laboratory of Oral Tissue Regeneration, Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Shandong University Jinan 250000, Shandong, China.
Jun LiPrecision Biomedical Laboratory, Department of Stomatology, Liaocheng People's Hospital, Liaocheng University Liaocheng 252000, Shandong, China.
Bingwu YangPrecision Biomedical Laboratory, Department of Stomatology, Liaocheng People's Hospital, Liaocheng University Liaocheng 252000, Shandong, China.
Li KongBiomedical Laboratory of Medical School, Liaocheng University Liaocheng 252000, Shandong, China.
Di ZhangPrecision Biomedical Laboratory, Department of Stomatology, Liaocheng People's Hospital, Liaocheng University Liaocheng 252000, Shandong, China.
Jianran GuoPrecision Biomedical Laboratory, Department of Stomatology, Liaocheng People's Hospital, Liaocheng University Liaocheng 252000, Shandong, China.
Longxun ZhouPrecision Biomedical Laboratory, Department of Stomatology, Liaocheng People's Hospital, Liaocheng University Liaocheng 252000, Shandong, China.
Guangliang BaiPrecision Biomedical Laboratory, Department of Stomatology, Liaocheng People's Hospital, Liaocheng University Liaocheng 252000, Shandong, China.
Huaqiang ZhaoShandong Provincial Key Laboratory of Oral Tissue Regeneration, Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Shandong University Jinan 250000, Shandong, China.
Zhen MengBiomedical Laboratory of Medical School, Liaocheng University Liaocheng 252000, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oral squamous cell carcinoma (OSCC) is one of the most common malignant tumors of the head and neck region. Plasmacytoma variant translocation 1 (PVT1), a long non-coding RNA (lncRNA), has been found to be overexpressed in multiple cancers, including OSCC. However, the upstream and downstream regulatory mechanisms through which PVT1 influences the malignant progression of OSCC remain to be further explored. In this study, PVT1 was confirmed to be overexpressed in OSCC tissues, and its roles in promoting OSCC cell proliferation, migration and invasion were identified. RNA-sequencing was used to screen the candidate target genes of PVT1, among which serpin family B member 4 (SERPINB4) was the most downregulated. SERPINB4 promoted OSCC cell proliferation, migration and invasion. In addition, mechanistic investigations demonstrated that PVT1 regulates SERPINB4 by sponging miR-185-5p in OSCC cells. Furthermore, SERPINB4 overexpression or miR-185-5p knockdown partly restores the decrease of OSCC cell proliferation and metastasis induced by PVT1 knockdown. Additional studies revealed that methyltransferase-like 3 (METTL3)-mediated N6-methyladenosine (m

Indexed as

m6A modificationMETTL3Oral squamous cell carcinomaPVT1SERPINB4

Identifiers

PMID40667541
PMCPMC12256411

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.