Evidence map›Paper›PMID 40667784›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Leptin Aggravates Thoracic Aortic Dissection Through Impairment of Energy Metabolism in Nrip2

Ling Chen, Yujie Zhu, Xi Yang, JiangBin Wu, Keyuan Chen, Wuqing Huang, Lu Fang, Qi Zhang, Jie Chen, Jianing Gao and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. [Independent Risk Factors for Venous Thromboembolism After Gynecological Surgery and the Predictive Value of Postoperative D-Dimer].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Article
  3. Review
  4. Leptin Aggravates Thoracic Aortic Dissection Through Impairment of Energy Metabolism in Nrip2Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Ling ChenDepartment of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, 350100, China.
Yujie ZhuThe Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, Peking University, Beijing, 100191, China.
Xi YangDepartment of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, 350100, China.
JiangBin WuDepartment of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, 350100, China.
Keyuan ChenDepartment of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, 350100, China.
Wuqing HuangDepartment of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, 350100, China.
Lu FangThe Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, Peking University, Beijing, 100191, China.
Qi ZhangThe Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, Peking University, Beijing, 100191, China.
Jie ChenThe Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, Peking University, Beijing, 100191, China.
Jianing GaoThe Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, Peking University, Beijing, 100191, China.
Huanhuan CaoThe Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, Peking University, Beijing, 100191, China.
Meifang WuDepartment of Cardiovascular, Affiliated Hospital of Putian University, Putian, Fujian, 351100, China.
Zhihuang QiuDepartment of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, 350100, China.
Yuling ZhangDepartment of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, 350100, China.
Yue ShenDepartment of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, 350100, China.
Qiuyu HuangDepartment of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, 350100, China.
Zhiyong LinCardiology Division, Emory University School of Medicine, 100 Woodruff Circle, Atlanta, GA, 30322, USA.
Lemin ZhengThe Institute of Cardiovascular Sciences and Institute of Systems Biomedicine, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, NHC Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, Beijing Key Laboratory of Cardiovascular Receptors Research, Health Science Center, Peking University, Beijing, 100191, China.ORCID https://orcid.org/0000-0003-4473-6936
Liangwan ChenDepartment of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou, 350100, China.

Funding

Fujian Medical University. The Startup Fund for Scientific Research 2023QH1031Fujian Medical University. The Startup Fund for Scientific Research 2023QH1038Fujian Medical University. The Startup Fund for Scientific Research 2023QH1321Fujian Provincial Department of Science and Technology. Joint Funds for the innovation of Science and Technology, Fujian province 2024Y92011000Fujian Provincial Department of Science and Technology. Joint Funds for the innovation of Science and Technology, Fujian province 2024Y9306Fujian Provincial Health Commission. Fujian provincial health technology project 2024GG01010163Fujian Provincial Health Commission. Fujian provincial health technology project 2024GGA019Ministry of Science and Technology of China 2020YFA0803700Ministry of Science and Technology of China 2023YFA1800904National Natural Science Foundation of China 81970425National Natural Science Foundation of China 82241209National Natural Science Foundation of China 82241210
6 · The paper itself

Abstract

Obesity is a significant risk factor for thoracic aortic dissection (TAD), as supported by UK Biobank data showing obese individuals have a higher risk of TAD. The study investigates leptin, a hormone elevated in obesity, and finds that hyperleptinemia is common in TAD patients, suggesting its role in disease pathogenesis. Using leptin-knockout mice, it is demonstrated that exogenous leptin exacerbates TAD by promoting phenotypic transitions in vascular smooth muscle cells (VSMCs). These adverse effects are reversible with pharmacologic leptin blockade, indicating potential therapeutic benefits. Single-cell RNA sequencing reveals a novel smooth muscle cells (SMC) cluster, Nrip2

Indexed as

Adaptor Proteins, Signal TransducingAortic Aneurysm, ThoracicAortic DissectionEnergy MetabolismLeptinMyocytes, Smooth MuscleAnimalsAorta, ThoracicDissection, Thoracic AortaHumansMaleMiceMice, Inbred C57BLMice, KnockoutMuscle, Smooth, VascularObesityAdaptor Proteins, Signal TransducingLeptinenergy metabolismleptinnuclear receptor interacting protein 2 (Nrip2)phenotypic transitionsthoracic aortic dissection (TAD)

Identifiers

PMID40667784
PMCPMC12520536

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.