Evidence map›Paper›PMID 40667841›Full record

ArticleEuropean journal of immunology2025

Fever-Induced Heat Shock Protein-70 Regulates Macrophage IL-1β and IL-10 Secretion During Mycobacterium tuberculosis Infection.

Deborah L W Chong, Sajeel A Shah, Julia Kutschenreuter, Ramla Cusman, Meena Murugananden Pillai, Daniela E Kirwan, Robert H Gilman, Jon S Friedland

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The cycle of infectious fever - how it affects bacterial infections.Frontiers in cellular and infection microbiology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Deborah L W ChongInstitute for Infection and Immunity, City St George's, University of London, London, UK.
Sajeel A ShahInstitute for Infection and Immunity, City St George's, University of London, London, UK.
Julia KutschenreuterInstitute for Infection and Immunity, City St George's, University of London, London, UK.
Ramla CusmanInstitute for Infection and Immunity, City St George's, University of London, London, UK.
Meena Murugananden PillaiInstitute for Infection and Immunity, City St George's, University of London, London, UK.
Daniela E KirwanInstitute for Infection and Immunity, City St George's, University of London, London, UK.ORCID 0000-0001-8785-8541
Robert H GilmanDepartment of International Health, Johns Hopkins University, Baltimore, Maryland, USA.
Jon S FriedlandInstitute for Infection and Immunity, City St George's, University of London, London, UK.

Funding

Medical Research Council (MRC) London Intercollegiate Doctoral Training Partnership (LID) MR/N013638/1Medical Research Council UK MR/P019978/2
6 · The paper itself

Abstract

Fever is a common clinical symptom in patients with tuberculosis (TB). During fever, heat-shock proteins (HSPs), such as HSP70, are expressed, which are molecular chaperones regulating protein folding and may also have immunomodulatory properties. How fever modulates immune responses during TB and by which mechanisms is unknown. In this study, we investigated the effects of fever, and specifically the role of HSP70, on Mycobacterium tuberculosis (Mtb)-induced macrophage inflammatory responses. Human monocyte-derived macrophages (MDM) were infected with Mtb at 37°C or 40°C to mimic febrile conditions. Fever suppresses Mtb-induced IL-1β and IL-10 gene expression and secretion from MDM, but enhances Mtb-induced HSP70 secretion and intracellular accumulation in MDM. Extracellular HSP70 and HSP70-expressing macrophages are abundant in granulomas in TB patient biopsies. HSP70 antagonism decreases Mtb-induced IL-1β secretion during febrile conditions but has no significant effect on IL-10 secretion. Pretreatment of MDM with recombinant HSP70 significantly increases Mtb-induced IL-1β at 37°C. Finally, extracellular HSP70 negatively regulates further HSP70 secretion from MDM during Mtb infection. Overall, fever and subsequent HSP70 expression modulates proinflammatory innate immune response in TB, which may have implications for the development of host-directed therapies.

Indexed as

FeverHSP70 Heat-Shock ProteinsInterleukin-10Interleukin-1betaMacrophagesMycobacterium tuberculosisTuberculosisCells, CulturedHumansImmunity, InnateHSP70 Heat-Shock ProteinsIL10 protein, humanIL1B protein, humanInterleukin-10Interleukin-1betacytokinesfeverheat shock proteinsinnate immunitytuberculosis

Identifiers

PMID40667841
PMCPMC12265389

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.