ReviewJournal of anesthesia2025
Effects of volatile and intravenous anesthetics on postoperative cognitive dysfunction: a mechanistic review.
Review in Journal of anesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prediction models for postoperative cognitive dysfunction in adults: a systematic review of methodological quality and clinical applicability.Frontiers in neurology · 2026Pooled it
- Advances in electroacupuncture for perioperative neurocognitive disorders: mechanisms and clinical evidence.Chinese medicine · 2026Review
- Transcranial Doppler ultrasonography in geriatric anesthesia: moving toward personalized brain protection strategies.Anesthesia and pain medicine · 2026Review
- Cognitive Changes in Laparoscopic Cholecystectomy: Cognitive Assessments in Decision-Making Matters.Journal of clinical medicine · 2026Article
- Critical Care Sedation: Emerging Clinical Considerations and Risks of Volatile Anesthetics for Sedation: A Narrative Review.Diseases (Basel, Switzerland) · 2026Review
- Postoperative neurocognitive disorder: migration and crosstalk of inflammation in the peripheral and central nervous system.Perioperative medicine (London, England) · 2026Review
- Association Between Preoperative Mechanical Bowel Preparation and Postoperative Cognitive Dysfunction in Patients Undergoing Colorectal Surgery: A Pilot Randomized Controlled Trial.Therapeutics and clinical risk management · 2026Article
- Diabetes and postoperative cognitive dysfunction and delirium in adults: mechanisms, biomarkers, and clinical management.Frontiers in endocrinology · 2026Review
- Mechanisms of natural compounds in treating inhalation anesthesia-induced cognitive dysfunction.Frontiers in pharmacology · 2026Review
- Downregulation of Gbp2 Attenuates LPS-Induced Inflammation in BV2 Microglia Cells Through Inhibition of STAT1.Journal of inflammation research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postoperative cognitive dysfunction (POCD) is a common neurological complication after surgery, with a higher incidence in elderly patients, significantly affecting postoperative recovery and quality of life. This article reviewed the potential mechanisms by which volatile and intravenous anesthetics affected POCD. We discussed mechanisms such as neuroinflammation, oxidative stress, region-specific brain alterations, neurotransmitter imbalances, and synaptic dysfunction, with an analysis of the distinct regulatory effects of both volatile and intravenous anesthetics. By comparing the roles of volatile and intravenous anesthetics, this review investigated the potential of personalized anesthesia strategies to improve cognitive function. Additionally, this review highlighted the use of multi-omics approaches, neuroimaging technologies, and artificial intelligence in POCD research, identified limitations, and promoted further investigation. By clarifying the mechanisms of anesthetic drugs, this review provided a scientific basis for clinical personalized anesthesia decision-making and laid the theoretical foundation for POCD intervention strategies.
Indexed as
Identifiers
40668243What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.