Evidence map›Paper›PMID 40668408›Full record

ReviewDiabetologia2025

Global perspectives on monogenic forms of diabetes.

James Russ-Silsby, Milena Teles, Samar S Hassan, Nancy S Elbarbary, Cấn Thị Bích Ngọc, Elisa De Franco

Abstract readReview
In one paragraph

Review in Diabetologia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

James Russ-SilsbyDepartment of Clinical and Biomedical Science, University of Exeter Medical School, Exeter, UK.ORCID http://orcid.org/0000-0002-4470-2544
Milena TelesGrupo de Diabetes Monogênico, Unidade de Endocrinologia Genética (LIM25), Unidade de Diabetes, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.ORCID http://orcid.org/0000-0002-0303-5335
Samar S HassanDepartment of Pediatric Endocrinology, Gaafar Ibn Auf Pediatric Tertiary Hospital, Khartoum, Sudan.ORCID http://orcid.org/0000-0002-9741-3383
Nancy S ElbarbaryDiabetes and Endocrine Unit, Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.ORCID http://orcid.org/0000-0001-8713-0657
Cấn Thị Bích NgọcVietnam National Children's Hospital, Hanoi, Vietnam.ORCID http://orcid.org/0009-0007-1404-0328
Elisa De FrancoDepartment of Clinical and Biomedical Science, University of Exeter Medical School, Exeter, UK. e.de-franco@exeter.ac.uk.ORCID http://orcid.org/0000-0002-1437-7891

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Monogenic forms of diabetes represent an uncommon but very heterogeneous subset of the disease, with variable associated clinical features and key differences in treatment options. In this review, we discuss how advances in precision medicine and genomic sequencing have enhanced our understanding of the aetiology and clinical variability of monogenic diabetes. We highlight current global challenges, including the over-representation of individuals of European genetic ancestry in research studies, which complicates diagnosis in non-European populations, and national disparities in genetic testing strategies, which influence diagnostic accuracy. Additionally, we address issues in variant interpretation stemming from the increased understanding of variable penetrance in monogenic diabetes and the need to expand current reference datasets to exclude common genetic variation. Finally, we explore future directions, including the potential benefits of ongoing genetic studies for under-represented populations, the benefits and potential pitfalls of newborn screening programmes, and the potential of stem cell-derived islet transplantation and glucagon-like peptide- 1 receptor agonists as treatments for some forms of monogenic diabetes.

Indexed as

Diabetes MellitusDiabetes Mellitus, Type 1Genetic TestingHumansPrecision MedicineDiagnosisEquity, diversity and inclusionGenetic testingGlobal challengesMODYMonogenic diabetesNeonatal diabetesPenetranceReview

Identifiers

PMID40668408
PMCPMC12534271

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.