ArticleArchives of osteoporosis2025
The relationship between type 2 diabetes mellitus, prediabetes, and bone mineral density in middle-aged and older adults: a nationwide study.
Article in Archives of osteoporosis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
This retrospective analysis of 11,595 individuals aged ≥ 50 years from the Taiwan Biobank demonstrated that prediabetes and type 2 diabetes mellitus (T2DM) were associated with higher bone mineral density (BMD). Prolonged T2DM duration correlated with increased lumbar spine BMD, while its effect on femoral neck BMD was nonsignificant after adjusting for confounding factors. PURPOSE: The relationship between T2DM, prediabetes and BMD has remained uncertain due to conflicting findings in previous research. This study aims to investigate the association between T2DM, prediabetes and BMD among middle-aged and older adults with Taiwan Biobank database.
methodsThe retrospective study included 11,595 patients aged ≥ 50 years from the Taiwan Biobank (2012-2021), comprising 2,476 in the control group, 6,877 in the prediabetes group, and 2,242 in the T2DM group. Categorical variables were analyzed with Pearson's chi-square, and continuous data was obtained using the Mann-Whitney U test. Significant variables (p < 0.05) in the univariate analysis were included in a multivariate logistic regression analysis. Patients with T2DM or prediabetes exhibited higher BMD at all measured sites compared to controls (p < 0.001).
resultsMultivariable analysis demonstrated that both conditions were independently associated with a lower osteoporosis rate. Individuals with T2DM for > 10 years had higher lumbar spine BMD compared to those with T2DM for 5-10 or < 5 years. However, T2DM duration > 10 years was associated with lower BMD at the bilateral femoral necks compared to those with a duration of 5-10 years. After adjusting for confounders, diabetes duration ≥ 10 years was no longer a significant predictor of lower femoral neck BMD. In the normal-weight category, individuals with T2DM had a significantly lower prevalence of osteoporosis than those with prediabetes and controls (p < 0.001). This inverse association was not observed in the underweight, overweight, or obese groups.
conclusionsPrediabetes and T2DM are correlated with higher BMD in middle-aged and older adults. A longer T2DM duration is associated with increased BMD at the lumbar spine but not the femoral neck after adjusting for confounders.
Indexed as
Identifiers
40668498What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.