Evidence map›Paper›PMID 40668865›Full record

Trial reportAmerican journal of respiratory and critical care medicine2025

Molecular Phenotyping of Sepsis and Differential Response to Fluid Resuscitation.

Elizabeth Kiernan, Leila R Zelnick, Ayesha Khader, Taylor D Coston, Zoie A Bailey, Sarah Speckmaier, Jordan J Lo, Edward D Siew, Neha A Sathe, Bryan R Kestenbaum and 6 more

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in American journal of respiratory and critical care medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Finding the Four-Leaf CLOVERS: Biologic Subphenotypes and Fluid Tolerance in Sepsis.American journal of respiratory and critical care medicine · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Elizabeth KiernanKidney Research Institute, Division of Nephrology, Department of Medicine.
Leila R ZelnickKidney Research Institute, Division of Nephrology, Department of Medicine.
Ayesha KhaderDepartment of Medicine.ORCID 0009-0008-4940-0386
Taylor D CostonDivision of Pulmonary, Critical Care and Sleep Medicine, and.ORCID 0000-0002-6155-4459
Zoie A BaileyDivision of Pulmonary, Critical Care and Sleep Medicine, and.
Sarah SpeckmaierDivision of Pulmonary, Critical Care and Sleep Medicine, and.
Jordan J LoDivision of Pulmonary, Critical Care and Sleep Medicine, and.
Edward D SiewDivision of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
Neha A SatheDivision of Pulmonary, Critical Care and Sleep Medicine, and.ORCID 0000-0002-9072-0559
Bryan R KestenbaumSepsis Center of Research Excellence.
Jonathan HimmelfarbDivision of Nephrology, Mount Sinai Hospital, New York, New York.
Nicholas J JohnsonDivision of Pulmonary, Critical Care and Sleep Medicine, and.ORCID 0000-0001-9915-0591
Nathan I ShapiroDepartment of Emergency Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts.
Ivor S DouglasPulmonary Science and Critical Care Medicine, Denver Health Medical Center, University of Colorado Anschutz Medical Campus, Denver, Colorado; and.
Catherine L HoughDivision of Pulmonary, Allergy, and Critical Care Medicine, Oregon Health & Science University, Portland, Oregon.
Pavan K BhatrajuKidney Research Institute, Division of Nephrology, Department of Medicine.

Funding

Identification and Validation of Biological Sub-phenotypes of Sepsis-induced Acute Kidney Injury: A Precision Medicine Approach to Improve Clinical OutcomesR01DK133177 · NIDDK · UNIVERSITY OF WASHINGTON · PI Pavan Kumar Bhatraju · 2022 to 2026
$2.6M
NIDDK NIH HHS R01 DK133177NIDDK NIH HHS R01DK133177
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Acute Kidney InjuryFluid TherapyResuscitationSepsisAgedAngiopoietin-2BiomarkersFemaleHumansMaleMiddle AgedPhenotypeTreatment OutcomeAngiopoietin-2Biomarkersacute kidney injuryendothelial dysfunctionsepsisvasopressorsvolume

Identifiers

PMID40668865
PMCPMC12432439

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.