Evidence map›Paper›PMID 40668917›Full record

ArticleScience advances2025

A Notch signal required for a morphological novelty in

Donya N Shodja, William J Glassford, Gavin Rice, Sarah J Smith, Mark Rebeiz

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Donya N ShodjaDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.ORCID 0000-0001-9284-1648
William J GlassfordDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.ORCID 0000-0003-4007-6731
Gavin RiceDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.ORCID 0000-0002-3527-4429
Sarah J SmithDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.ORCID 0000-0002-1469-1821
Mark RebeizDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.ORCID 0000-0001-5731-5570

Funding

Deconstructing and recapitulating the genetic basis of gene regulatory network redeploymentK99GM147343 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RICE, GAVIN RYAN · 2022 to 2023
$225k
NIGMS NIH HHS K99 GM147343
6 · The paper itself

Abstract

The origin of morphological novelties has long fascinated biologists. Signaling pathways play important roles in the formation of novelties; however, the history of how they become integrated into new developmental programs remains unclear. Here, we investigated the evolution of the posterior lobe, a novel structure in the male genitalia of

Indexed as

Drosophila melanogasterDrosophila ProteinsGenitalia, MaleReceptors, NotchSignal TransductionAnimalsGene Expression Regulation, DevelopmentalIntracellular Signaling Peptides and ProteinsMaleMembrane Proteinsdelta proteinDrosophila ProteinsIntracellular Signaling Peptides and ProteinsMembrane ProteinsReceptors, Notch

Identifiers

PMID40668917
PMCPMC12266118

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.