ArticleScientific reports2025
Microwave assisted solvothermal green synthesis of Fe
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- In vitro and in silico evaluation of the synergistic effect of Cytarabine and Zataria multiflora Boiss extract on pre-B acute lymphoblastic leukemia cells (NALM-6 cell line).Medical oncology (Northwood, London, England) · 2026Article
- Novel green synthesized agar/alginate biopolymer hydrogel-based magnetic composite beads for biomedical, environmental, and electrical applications.RSC advances · 2026Article
- Aptamer-mediated targeting of CXCR3-B in acute lymphoblastic leukemia nalm-6 cells: an in silico and in vitro study.Molecular biology reports · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study presents a microwave-solvothermal green synthesis of magnetite (Fe₃O₄) nanoparticles (NPs) using Hippophae rhamnoides berry extract and evaluates their selective anticancer activity. The NPs exhibited a crystalline structure (XRD peaks matching JCPDS Card No. 88-0315), superparamagnetic properties (VSM: saturation magnetization 40.32 emu/g), with a primary particle size of 15.6 nm (TEM) and a hydrodynamic diameter of 93.25 nm (DLS). FTIR confirmed surface functionalization, with Fe-O bands and organic groups indicating phytochemical adsorption. In vitro assays (MTT, BrdU, Annexin V-PI) on U266 (multiple myeloma), THP-1 (acute monocytic leukemia), and L-929 (normal fibroblast) cells showed dose- and time-dependent cytotoxicity, with U266 and THP-1 viability reduced to 15.3% and 14.2% at 150 µg/mL after 48 h, respectively, while L-929 viability remained at 86.9%. Flow cytometry revealed late apoptosis as the primary cell death mechanism (86.6% in U266, 66.5% in THP-1 at 150 µg/mL), driven by caspase-3 activation and oxidative stress (elevated TOS and MDA levels). These findings demonstrate the potential of these NPs as selective anticancer agents for hematological malignancies, supported by their physicochemical and biological properties.
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Registered trials
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