Evidence map›Paper›PMID 40670782›Full record

Trial reportNature2025

Longer scans boost prediction and cut costs in brain-wide association studies.

Leon Qi Rong Ooi, Csaba Orban, Shaoshi Zhang, Thomas E Nichols, Trevor Wei Kiat Tan, Ru Kong, Scott Marek, Nico U F Dosenbach, Timothy O Laumann, Evan M Gordon and 19 more

Abstract readClinical Trial
In one paragraph

Trial report in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Dilating the aging clock with light.Innovation (Cambridge (Mass.)) · 2026
    Review
  7. Observational
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Review
  18. Article
  19. The Hidden Landscape of Missed Effects in Human Functional Neuroimaging.bioRxiv : the preprint server for biology · 2026
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors.

Leon Qi Rong Ooi *Integrative Sciences and Engineering Programme (ISEP), National University of Singapore, Singapore, Singapore.ORCID 0000-0002-3546-4580
Csaba Orban *Centre for Sleep and Cognition & Centre for Translational MR Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Shaoshi Zhang *Integrative Sciences and Engineering Programme (ISEP), National University of Singapore, Singapore, Singapore.ORCID 0000-0002-6352-9150
Thomas E NicholsBig Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford, Oxford, UK.ORCID 0000-0002-4516-5103
Trevor Wei Kiat TanIntegrative Sciences and Engineering Programme (ISEP), National University of Singapore, Singapore, Singapore.
Ru KongCentre for Sleep and Cognition & Centre for Translational MR Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0001-7842-0329
Scott MarekMallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA.
Nico U F DosenbachMallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-6876-7078
Timothy O LaumannAllied Labs for Imaging Guided Neurotherapies (ALIGN), Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-0428-427X
Evan M GordonMallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-2276-5237
Kwong Hsia YapMemory, Ageing and Cognition Centre, National University Health System, Singapore, Singapore.
Fang JiCentre for Sleep and Cognition & Centre for Translational MR Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Joanna Su Xian ChongCentre for Sleep and Cognition & Centre for Translational MR Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0009-0008-5077-5206
Christopher ChenMemory, Ageing and Cognition Centre, National University Health System, Singapore, Singapore.ORCID 0000-0002-1047-9225
Lijun AnDepartment of Clinical Sciences, Malmö, SciLifeLab, Lund University, Lund, Sweden.ORCID 0000-0003-1030-4625
Nicolai FranzmeierInstitute for Stroke and Dementia Research, LMU Munich, Munich, Germany.
Sebastian N Roemer-CassianoInstitute for Stroke and Dementia Research, LMU Munich, Munich, Germany.ORCID 0000-0003-3423-457X
Qingyu HuChangping Laboratory, Beijing, China.ORCID 0009-0007-5968-7854
Jianxun RenChangping Laboratory, Beijing, China.ORCID 0000-0002-7885-4546
Hesheng LiuChangping Laboratory, Beijing, China.ORCID 0000-0002-7233-1509
Sidhant ChopraOrygen, Melbourne, Victoria, Australia.
Carrisa V CocuzzaDepartment of Psychology, Yale University, New Haven, CT, USA.
Justin T BakerDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
Juan Helen ZhouIntegrative Sciences and Engineering Programme (ISEP), National University of Singapore, Singapore, Singapore.ORCID 0000-0002-0180-8648
Danilo BzdokThe Neuro, McConnell Brain Imaging Centre, Department of Biomedical Engineering, Montreal, Quebec, Canada.ORCID 0000-0003-3466-6620
Simon B EickhoffInstitute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Center Jülich, Jülich, Germany.
Avram J HolmesDepartment of Psychiatry, Brain Health Institute, Rutgers University, Piscataway, NJ, USA.
B T Thomas YeoIntegrative Sciences and Engineering Programme (ISEP), National University of Singapore, Singapore, Singapore. thomas.yeo@nus.edu.sg.ORCID 0000-0002-0119-3276
Alzheimer’s Disease Neuroimaging Initiative

Funding

Project 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI MICHAEL W WEINER · 2016 to 2026
$226.7M
ABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$52.0M
ABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5M
Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
Adolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5M
ABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7M
Prospective Research Studies of Maturation (PRISM)- Research ProjectU01DA041134 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ERIN MCGLADE, PERRY FRANKLIN RENSHAW · 2015 to 2026
$29.2M
ABCD-USA CONSORTIUM: RESEARCH PROJECTU01DA041048 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Megan Marie Herting, ELIZABETH R SOWELL · 2015 to 2026
$28.7M
ABCD-USA Consortium: Research ProjectU01DA041106 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mary M Heitzeg, Chandra Sekhar Sripada · 2015 to 2026
$24.9M
FIU-ABCD: Pathways and Mechanisms to Addiction in the Latino Youth of South FloridaU01DA041156 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI Raul Gonzalez, Angela R Laird · 2015 to 2026
$22.8M
ABCD-USA Consortium: Research ProjectU01DA041148 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Damien A Fair, Rebekah S Huber · 2015 to 2026
$22.3M
ABCD-USA: NYC Research ProjectU01DA041174 · NIDA · YALE UNIVERSITY · PI Arielle Ryan Baskin-Sommers, Betty J Casey · 2015 to 2026
$19.7M
NIA NIH HHS U19 AG024904NIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041025NIDA NIH HHS U01 DA041028NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041089NIDA NIH HHS U01 DA041093NIDA NIH HHS U01 DA041106NIDA NIH HHS U01 DA041117NIDA NIH HHS U01 DA041120NIDA NIH HHS U01 DA041134NIDA NIH HHS U01 DA041148NIDA NIH HHS U01 DA041156NIDA NIH HHS U01 DA041174NIDA NIH HHS U01 DA050987NIDA NIH HHS U01 DA050988NIDA NIH HHS U01 DA050989NIDA NIH HHS U01 DA051016NIDA NIH HHS U01 DA051018NIDA NIH HHS U01 DA051037NIDA NIH HHS U01 DA051038NIDA NIH HHS U01 DA051039NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147NIMH NIH HHS K99 MH121518NIMH NIH HHS K99 MH129616NIMH NIH HHS R00 MH121518NIMH NIH HHS R00 MH129616NIMH NIH HHS R01 MH096773NIMH NIH HHS R01 MH120080NIMH NIH HHS R01 MH133334NIMH NIH HHS R44 MH121276NIMH NIH HHS R44 MH122066NIMH NIH HHS R44 MH124567NIMH NIH HHS U54 MH091657NINDS NIH HHS P01 NS131131NINDS NIH HHS R01 NS140256NINDS NIH HHS R44 NS129521
6 · The paper itself

Abstract

A pervasive dilemma in brain-wide association studies

Indexed as

BrainGenome-Wide Association StudyMagnetic Resonance ImagingAdultCost-Benefit AnalysisFemaleHumansMalePhenotypeRestSample SizeTime Factors

Identifiers

PMID40670782
PMCPMC12367542

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.