Evidence map›Paper›PMID 40671476›Full record

ReviewHistology and histopathology2026

Tau aggregation.

Indalo Domene-Serrano, Ismael Santa-María, Felix Hernandez, Jesús Avila

Abstract readReview
PubMed Publisher
In one paragraph

Review in Histology and histopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Indalo Domene-SerranoCentro de Biología Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain.
Ismael Santa-MaríaFacultad de Ciencias Experimentales, Universidad Francisco de Vitoria, Pozuelo de Alarcon, Madrid, Spain.
Felix HernandezFacultad de Ciencias Experimentales, Universidad Francisco de Vitoria, Pozuelo de Alarcon, Madrid, Spain.
Jesús AvilaCentro de Biología Molecular Severo Ochoa, CSIC-UAM, Madrid, Spain.

Funding

FEDER, UE MCIN/AEI/10.13039/501100011033Severo Ochoa Center of Excellence CEX2021-001154-SSpanish Ministry of Science PID2020-113204GB-I00Spanish Ministry of Science PID2021-123859OB-100
6 · The paper itself

Abstract

Microtubule-associated protein tau is predominantly expressed in neurons in the form of multiple isoforms generated by alternative splicing. These isoforms differ in the presence of either three or four microtubule-binding repeats. These binding regions not only regulate tau's interaction with microtubules but are also critically involved in its pathological self-aggregation. Such aggregates are a defining feature of a group of neurodegenerative disorders collectively referred to as tauopathies. In this work, we examine the mechanisms underlying tau self-aggregation, the molecular and cellular factors that drive this process, and the structural features of tau aggregates. Aggregates composed of isoforms with three

Indexed as

Protein Aggregation, PathologicalTauopathiestau ProteinsAnimalsHumansMicrotubulesNeuronsProtein AggregatesProtein IsoformsProtein AggregatesProtein Isoformstau Proteins

Identifiers

PMID40671476

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.