Evidence map›Paper›PMID 40671663›Full record

SynthesisInternational health2026

Susceptible window identification of the relationship between maternal ozone exposure and preterm birth.

Kang-Kang Zhong, Rui Yang, Xue-Chun Liu, Jie He, Chuan-Ting Wen, Zhi-Wei Zhu, Ming-Xuan Fan, Teng Bao, Qi Zhong

Abstract readMeta-Analysis
In one paragraph

Synthesis in International health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kang-Kang ZhongSchool of Public Health, Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei, Anhui Province, China.
Rui YangSchool of Public Health, Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei, Anhui Province, China.
Xue-Chun LiuDepartment of Neurology, Second People's Hospital of Hefei, Hefei Hospital Affiliated to Anhui Medical University, No. 199 Changjiang East Road, Yaohai District, Hefei, Anhui Province, China.
Jie HeSchool of Public Health, Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei, Anhui Province, China.
Chuan-Ting WenSchool of Public Health, Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei, Anhui Province, China.
Zhi-Wei ZhuJiangsu Province Hospital of Chinese Medicine, No. 155 Hanzhong Road, Gulou District, Nanjing, Jiangsu Province, China.
Ming-Xuan FanSchool of Public Health, Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei, Anhui Province, China.
Teng BaoSecond School of Clinical Medicine, Anhui Medical University, 81 Meishan Road, Shushan District, Hefei, Anhui Province, China.
Qi ZhongSchool of Public Health, Anhui Medical University, No. 81 Meishan Road, Shushan District, Hefei, Anhui Province, China.

Funding

National Natural Science Foundation of China 82404223Noncommunicable Chronic Diseases-National Science and Technology Major Project 2023ZD0518800
6 · The paper itself

Abstract

Previous studies have focused on the effects of ozone (O3) exposure and preterm birth (PTB), but the findings are contentious and the susceptible window for O3 exposure during pregnancy remains inconclusive. Here, we pooled the current evidence to explore the relationship between maternal O3 exposure and PTB and further identified the susceptible exposure windows. We pooled a meta-analysis of 17 eligible studies by searching Embase, PubMed and Web of Science through 9 September 2024. The odds ratio (OR) and the corresponding 95% confidence intervals (CIs) were extracted for analysis. The tests for heterogeneity, sensitivity and publication bias between studies were performed using Stata 15.0 (StataCorp, College Station, TX, USA). The combined results showed a positive association between O3 exposure and PTB (n=13; OR 1.065 [95% CI 1.056 to 1.073]), and middle pregnancy (gestational weeks 13-27) may be a susceptible window of O3 exposure with PTB (n=11; OR 1.033 [95% CI 1.029 to 1.036]). This meta-analysis suggested that O3 exposure during pregnancy may independently increase the risk of PTB and gestational weeks the 13-27 is a critical window for preventing this risk. Reducing outdoor activity or a wearing protective mask and multiple micronutrients supplementation during pregnancy may reduce the risk of O3 exposure in PTB.

Indexed as

Air PollutantsMaternal ExposureOzonePremature BirthFemaleHumansInfant, NewbornPregnancyAir PollutantsOzonemeta-analysisO3 exposurepreterm birthsusceptible window

Identifiers

PMID40671663
PMCPMC13016642

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.