Evidence mapPaperPMID 40671685Full record

ReviewJournal of cosmetic dermatology2025

Advances in Longevity: The Intersection of Regenerative Medicine and Cosmetic Dermatology.

Diala Haykal, Frederic Flament, Mukta Shadev, Pascale Mora, Cristina Puyat, Brigitte Dréno, Qian Zheng, Hugues Cartier, Michael Gold, Steven Cohen

Abstract readReview
In one paragraph

Review in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Diala HaykalCentre Laser Palaiseau, Palaiseau, France.ORCID https://orcid.org/0000-0001-7528-5088
Frederic FlamentL'Oréal Research and Innovation, Clichy, France.
Mukta ShadevManipal Hospital Bangalore, Bangalore, India.ORCID https://orcid.org/0009-0004-7420-4409
Pascale MoraL'Oréal Research and Innovation, Clichy, France.
Cristina PuyatAsian Stem Cell Institute Inc., Metro Manila, Philippines.
Brigitte DrénoNantes Université, INSERM, CNRS, Immunology and New Concepts in ImmunoTherapy, INCIT, Nantes, France.
Qian ZhengL'Oreal Research and Innovation, Clark, New Jersey, USA.
Hugues CartierPrivate Practice, Centre Médical Saint Jean d'Arras, Arras, France.
Michael GoldClinical Research Center, Gold Skin Care Center, Nashville, Tennessee, USA.ORCID https://orcid.org/0000-0002-5183-5433
Steven CohenFACES+ Plastic Surgery, Skin and Laser Center, Division of Plastic Surgery, University of California, San Diego, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAging is increasingly recognized as a modifiable biological process influenced by genetic, environmental, and lifestyle factors. Recent advances in regenerative medicine and artificial intelligence (AI) have reshaped the field of cosmetic dermatology, shifting the focus from temporary aesthetic improvements to long-term interventions aimed at preserving skin vitality and longevity.

aimThis narrative review aims to synthesize emerging knowledge from 2010 to 2025 on the integration of regenerative strategies, biological modulators, immunologic regulation, microbiome modulation, and AI-driven personalization in the context of aesthetic longevity. The review also discusses translational potential and ethical considerations surrounding these advancements.

methodsA targeted literature search was conducted using PubMed and Scopus to identify peer-reviewed articles from 2010 to 2025. Search terms included "skin aging," "stem cells," "mitochondrial dysfunction," "epigenetic reprogramming," "artificial intelligence in dermatology," and "skin microbiome." Selected studies focused on regenerative and longevity-based interventions with clinical relevance or future applicability in cosmetic dermatology.

resultsKey findings were categorized into six interconnected domains: regenerative medicine, mitochondrial function, epigenetic modulation, immunological balance, microbiome resilience, and AI-driven innovation. These pillars demonstrate a paradigm shift toward biologically informed, personalized strategies that aim to restore and sustain skin health at the molecular level.

conclusionCosmetic dermatology is undergoing a transformation toward integrative, proactive care that combines regenerative medicine, AI, and personalized interventions. These approaches offer promising, evidence-based solutions for enhancing both aesthetic outcomes and long-term skin function, while also raising important ethical and regulatory considerations for clinical implementation.

Indexed as

Cosmetic TechniquesDermatologyLongevityRegenerative MedicineSkin AgingArtificial IntelligenceHumansMicrobiotaPrecision MedicineRejuvenationSkincosmetic dermatologycosmetic legislationscosmetic surgerydermatologyregenerative medicinestem cells

Identifiers

PMID40671685
PMCPMC12268380

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.