SynthesisFrontiers in physiology2025
Platelet rich plasma injections for knee osteoarthritis: an overview of systematic reviews.
Synthesis in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Cord Blood-Derived Versus Homologous Donor Platelet-Rich Plasma (PRP) in Early Knee Osteoarthritis: A Single-Center, Randomized, Double-Blind Pilot Clinical Trial.Bioengineering (Basel, Switzerland) · 2026Article
- Pharmacological Agents for Soft Tissue and Articular Injections: From Mechanisms to Clinical Applications.Journal of clinical medicine · 2026Review
- Comparison of clinical efficacy of sequential and single intra-articular injection of platelet-rich plasma in treatment of early/mid-stage knee osteoarthritis.Frontiers in medicine · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Knee osteoarthritis (KOA) is a prevalent degenerative joint disease, particularly affecting the aging population. While numerous systematic reviews (SRs) and meta-analyses (MAs) have evaluated the efficacy and safety of platelet-rich plasma (PRP) for KOA, the methodological quality and potential biases of these syntheses require critical assessment. Methods: We conducted an overview of SRs/MAs on PRP for KOA. Comprehensive searches were performed in PubMed, Embase, The Cochrane Library, and Web of Science from inception to December 1, 2024. Two reviewers independently screened literature and extracted data. The methodological quality of included SRs/MAs was evaluated using AMSTAR-2, the degree of primary study overlap was assessed using the GROOVE tool, and the risk of bias in the primary randomized trials was evaluated using the ROB 2.0 tool. Result: A total of 29 SRs/MAs met the inclusion criteria. GROOVE analysis revealed a very high degree of overlap among the primary studies included across the reviews. AMSTAR-2 assessment demonstrated critically low methodological quality for 26 reviews and low quality for the remaining 3 reviews. Discussion: The current quality of SRs/MAs on PRP for KOA remains suboptimal. Future studies should adhere closely to established evaluation frameworks including AMSTAR2 to enhance research reliability and clinical applicability. Systematic Review Registration: https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42024619416.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.