ArticleFrontiers in veterinary science2025
Evaluation of the efficacy of icariin against heat stress-induced spermatogenic dysfunction in the testes of dogs.
Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Dietary Arginine Supplementation Mitigates Heat Stress-Induced Testicular Dysfunction Through Arginine-Related Metabolic Remodeling and Autophagy-Associated Stress Adaptation in a Rongchang Boar Model.Animals : an open access journal from MDPI · 2026Article
- Environmental stress and stallion fertility: mechanistic insights, evidence gaps, and functional implications.Frontiers in veterinary science · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: This study examines the detrimental effects of high-temperature environments on canine testicular function and reproductive health, and investigates the potential of Methods: A completely randomized single-factor design was employed, involving 24 adult male Beagle dogs (9.82 ± 0.73 kg) assigned randomly to four treatment groups, with six dogs in each group. The groups included a negative control group ("Control"), a positive control group exposed to testicular heat stress ("Model"), and two icariin-treated groups receiving daily doses of 0.5 g/kg (Icariin-L) and 1.0 g/kg (Icariin-H), respectively. All groups, except the negative control, underwent a testicular heat stress model to induce damage and assess the effects of icariin on sperm quality, testicular function, hormone levels, protein expression, and testicular histological changes. Results: Icariin supplementation improved sperm quality under heat stress, as indicated by increased total sperm count and motility, along with a reduction in sperm malformation rate ( Conclusion: These findings suggest that icariin may alleviate testicular heat stress by modulating testosterone synthesis, enhancing ATPase function, restoring blood-testis barrier integrity, and inhibiting apoptosis. The dose-dependent efficacy (1.0 g/kg > 0.5 g/kg) supports the potential of icariin as a possible therapeutic agent for improving reproductive health in dogs exposed to high-temperature environments.
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Registered trials
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