ReviewJournal of cell communication and signaling2025
A comprehensive analysis of the relationship between inflammasomes and autophagy in human tumors: Recent developments.
Review in Journal of cell communication and signaling, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- The Mechanistic Crosstalk between Probiotics, ncRNAs, and Autophagy: Implications for Colorectal Cancer Precision Medicine.Expert reviews in molecular medicine · 2026Review
- A comprehensive analysis of the relationship between inflammasomes and autophagy in human tumors: Recent developments.Journal of cell communication and signaling · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autophagy and inflammasomes are essential cellular mechanisms that maintain homeostasis, regulate immune responses, and influence disease progression, especially in cancer. Autophagy, a lysosome-mediated process, removes damaged organelles and misfolded proteins, allowing cells to adapt to stress. This involves autophagosome formation, fusion with lysosomes, and subsequent degradation of cellular cargo. In contrast, inflammasomes are multiprotein complexes of the innate immune system that detect pathogenic signals and cellular stress, initiating inflammatory cytokine release to facilitate tissue repair. Notably, both pathways play dual roles in cancer: Although they help preserve cellular integrity and suppress tumorigenesis, they may also promote tumor survival under adverse conditions. This review explores the molecular mechanisms underlying autophagy and inflammasome activity, emphasizing their complex interplay and regulatory networks within the tumor microenvironment.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.