ArticleJournal of gastrointestinal oncology2025
Peripheral blood neutrophil-to-lymphocyte ratio as a prognostic marker and its association with the tumor-immune microenvironment in pancreatic cancer: a retrospective cohort study.
Article in Journal of gastrointestinal oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- On-Treatment NLR Dynamics During CDK4/6 Inhibition Are Associated with Overall Survival in Metastatic Breast Cancer.Cancers · 2026Article
- The Global Immune-Nutrition-Inflammation Index Is Associated with Survival Outcomes and Enhances Prognostic Discrimination in Metastatic Pancreatic Cancer.Medicina (Kaunas, Lithuania) · 2026Article
- Development and validation of nomograms integrating electrolyte, nutritional, and inflammatory indicators to predict survival in advanced esophageal cancer undergoing immunotherapy or radioimmunotherapy.Journal of thoracic disease · 2026Article
- Rethinking PDAC: from immunological silence to therapeutic opportunity.Frontiers in immunology · 2026Review
- An Inflammation-Associated Prognostic Model for Hepatocellular Carcinoma Following Radical Resection.Journal of hepatocellular carcinoma · 2026Article
- Baseline inflammatory and metabolic indicators associated with early PD-1 inhibitor resistance in advanced cervical cancer: a retrospective cohort study.Frontiers in medicine · 2026Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: An elevated peripheral blood neutrophil-to-lymphocyte ratio (NLR) has been reported to be a negative prognostic marker in many types of cancer, including pancreatic ductal adenocarcinoma (PDAC). However, whether NLR is associated with the tumor-immune microenvironment (TIME) in PDAC is unclear. Understanding the interplay between systemic inflammation as reflected by NLR and TIME in PDAC is crucial for identifying prognostic biomarkers and potential therapeutic targets. The aim of this study was to examine the relationship between the NLR and clinical outcomes in patients with early-stage PDAC and the impact of the TIME in PDAC. Methods: We conducted a retrospective analysis including two cohorts: PDAC patients versus healthy controls and untreated stage I-II PDAC cases. We collected clinical data, including NLR values and followed PDAC patients for overall survival (OS) and relapse-free survival (RFS), and the TIME was evaluated through immunohistochemical staining for CD8 Results: NLR was negatively associated with OS and RFS in patients with PDAC. Moreover, NLR was found to be a prognostic factor for PDAC and early-stage PDAC. The NLR was inversely correlated with the abundance of tumoral CD8 Conclusions: Our findings indicate that a high NLR value is closely correlated with poor outcomes in patients with PDAC. In addition, it was significantly associated with the presence of tumoral CD8
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.