Evidence map›Paper›PMID 40672256›Full record

ArticlebioRxiv : the preprint server for biology2025

Structure-activity Relationship for Diarylpyrazoles as Inhibitors of the Fungal Kinase Yck2.

David J Shirley, Bonnie Yiu, Ikeer Mancera-Ortiz, Peter J Stogios, Zhongle Liu, Nicole Robbins, Luke Whitesell, Leah E Cowen, David H Drewry, Timothy M Willson

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

David J ShirleyStructural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0009-0003-2475-7366
Bonnie YiuDepartment of Molecular Genetics, University of Toronto, Toronto, ON, M5G 1M1, Canada.ORCID 0009-0004-9106-9974
Ikeer Mancera-OrtizStructural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0009-0005-7877-8562
Peter J StogiosDepartment of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, ON, M5G 1M1, Canada.ORCID 0000-0001-8663-1425
Zhongle LiuDepartment of Molecular Genetics, University of Toronto, Toronto, ON, M5G 1M1, Canada.ORCID 0000-0003-4198-8214
Nicole RobbinsDepartment of Molecular Genetics, University of Toronto, Toronto, ON, M5G 1M1, Canada.ORCID 0000-0003-2821-9269
Luke WhitesellDepartment of Molecular Genetics, University of Toronto, Toronto, ON, M5G 1M1, Canada.ORCID 0000-0001-6445-5766
Leah E CowenDepartment of Molecular Genetics, University of Toronto, Toronto, ON, M5G 1M1, Canada.ORCID 0000-0001-5797-0110
David H DrewryStructural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0001-5973-5798
Timothy M WillsonStructural Genomics Consortium and Division of Chemical Biology and Medicinal Chemistry, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.ORCID 0000-0003-4181-8223

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Targeting the casein kinase 1 (CK1)-like kinase Yck2 in fungal pathogenesisR01AI162789 · NIAID · UNIVERSITY OF TORONTO · PI LEAH Elizabeth Cowen, Timothy M Willson · 2022 to 2026
$3.1M
Elucidating the mechanism of action of novel ClpP activators in activation of the mitochondrial unfolded protein response.R01GM138520 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI GRAVES, LEE M · 2020 to 2023
$1.3M
Request for a 500 MHz NMR console and nitrogen-cooled cryoprobeS10OD032476 · OD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LEE, ANDREW L · 2022 to 2022
$599k
NCI NIH HHS P30 CA016086NIAID NIH HHS R01 AI162789NIGMS NIH HHS R01 GM138520NIH HHS S10 OD032476
6 · The paper itself

Abstract

Candida albicans is a growing global health threat, causing 1.5 million invasive infections and 1 million deaths annually. Yeast casein kinase 2 (Yck2) in

Indexed as

Antifungaldiarylpyrazolekinase inhibitor

Identifiers

PMID40672256
PMCPMC12265645

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.