ArticlebioRxiv : the preprint server for biology2025
Resolving ScRNA-Seq Signatures of Antigen-Specific CD4
Michael S Andrade, Grace E Hynes, Zara R Suran, Dengping Yin, Maria-Luisa Alegre, Peter T Sage, Anita S Chong
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
7 authors.
Michael S AndradeSection of Transplantation, Department of Surgery, The University of Chicago, 60637.ORCID 0000-0002-1404-3015 Grace E HynesSection of Transplantation, Department of Surgery, The University of Chicago, 60637.
Zara R SuranSection of Transplantation, Department of Surgery, The University of Chicago, 60637.
Dengping YinSection of Transplantation, Department of Surgery, The University of Chicago, 60637.
Maria-Luisa AlegreSection of Rheumatology, Department of Medicine, The University of Chicago, 60637.
Peter T SageTransplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, 02115.
Anita S ChongSection of Transplantation, Department of Surgery, The University of Chicago, 60637.
Funding
VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI KUNLE ODUNSI · 1985 to 2026
$122.1MT cell mechanisms that distinguish robust tolerance from metastable allograft acceptance and failed tolerance (Project 2)P01AI097113 · NIAID · UNIVERSITY OF CHICAGO · PI Maria-Luisa Alegre, Anita S Chong · 2012 to 2026
$23.8McGMP Manufacture, Fill-Finish, Release, Analytical and Stability Testing and Stability Program of a Nanoparticle Based HIV Envelope Vaccine75N93022D00005 · NIAID · INTERNATIONAL AIDS VACCINE INITIATIVE · PI HASSELL, THOMAS · 2022 to 2025
$8.0MTask Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin75N92020D00005 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL E · 2020 to 2025
$5.1MIntrarenal B cells in acute kidney allograft rejectionR01AI148705 · NIAID · UNIVERSITY OF CHICAGO · PI CHONG, ANITA S, CLARK, MARCUS RAMSAY · 2020 to 2024
$4.0MMechanistic studies on pregnancy-induced humoral sensitization in organ transplantationR01AI182097 · NIAID · UNIVERSITY OF CHICAGO · PI Anita S Chong · 2024 to 2026
$2.5MNCI NIH HHS P30 CA014599NHLBI NIH HHS 75N92020D00005NIAID NIH HHS 75N93022D00005NIAID NIH HHS 75N93023D00005NIAID NIH HHS P01 AI097113NIAID NIH HHS R01 AI148705NIAID NIH HHS R01 AI182097NIDA NIH HHS 75N95020D00005ORFDO NIH HHS 75N99020D00005
6 · The paper itselfAbstract
Transplantation of allogeneic organs requires lifelong immunosuppression to prevent rejection. Prior sensitization and resultant memory T cells are barriers to achieving successful transplant tolerance. In reproductive immunology by contrast, pregnancy represents a spontaneous model of tolerance where the semi-allogeneic fetus evades rejection even in multiparous or rejection-sensitized mothers. CD8
Identifiers
PMID40672265
PMCPMC12265706
What Socratic holds
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