Evidence map›Paper›PMID 40672286›Full record

ArticlebioRxiv : the preprint server for biology2025

Loss of FMRP in microglia promotes degeneration of parvalbumin neurons and audiogenic seizures via progranulin insufficiency.

Heng Li, Jennifer Ja-Yoon Choi, Eric J Huang, Baoji Xu

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Heng LiDepartment of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, FL, USA.
Jennifer Ja-Yoon ChoiDepartment of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA.
Eric J HuangDepartment of Pathology & Immunology, Washington University School of Medicine, St Louis, MO, USA.
Baoji XuDepartment of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, Jupiter, FL, USA.ORCID 0000-0002-2416-6633

Funding

Endolysosomal defects in secretory autophagy and microglial toxicity in FTDR01AG057462 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jayanta Debnath, Eric J Huang · 2017 to 2026
$6.9M
Molecular and cellular basis for autism spectrum disorders caused by exacerbated translationR01MH125187 · NIMH · UNIVERSITY OF FLORIDA · PI RUMBAUGH, GAVIN R, XU, BAOJI · 2020 to 2024
$2.7M
Endolysosomal trafficking and lipid metabolism defects in FTLDR01AG081452 · NIA · WASHINGTON UNIVERSITY · PI Eric J Huang · 2023 to 2026
$2.7M
NIA NIH HHS R01 AG057462NIA NIH HHS R01 AG081452NIMH NIH HHS R01 MH125187
6 · The paper itself

Abstract

Fragile X syndrome (FXS) results from loss of FMR1-encoded FMRP and is associated with reduced density of parvalbumin (PV) neurons; however, the mechanism underlying this abnormality remains unknown. Here we report that microglial FMRP regulates PV neuron density through lysosomal function. Mice with

Identifiers

PMID40672286
PMCPMC12265543

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.