Evidence map›Paper›PMID 40672371›Full record

ReviewFrontiers in pharmacology2025

Research progress on peptides that inhibit melanin synthesis.

Binrui Yu, Nailong Wang, Shanshan Cai, Hao Yan, Shaojia Sun, Siru Wang, Ye Li, Zhengting Liang

Abstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Binrui YuCollege of Pharmacy, Xinjiang Medical University, Urumqi, China.
Nailong WangCollege of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, China.
Shanshan CaiDivision of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, United Kingdom.
Hao YanInstitute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen, China.
Shaojia SunCollege of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, China.
Siru WangCollege of Public Health, Xinjiang Medical University, Urumqi, China.
Ye LiCollege of Bioengineering, Sichuan University of Science and Engineering, Yibin, China.
Zhengting LiangCollege of Traditional Chinese Medicine, Xinjiang Medical University, Urumqi, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melanin produced by melanocytes, primarily determines human skin color and protects against ultraviolet radiation. However, excessive melanin deposition can lead to skin conditions such as freckles, age spots, and moles, potentially causing aesthetic concerns and psychological distress. Consequently, there is significant research interest in developing safe and effective whitening products that inhibit melanin synthesis. Bioactive peptides represent a promising compound category that effectively reduces melanin synthesis with minimal side effects. This review explores melanin pigmentation, identifies sources of peptides that inhibit melanin synthesis, and elucidates the mechanisms by which these peptides operate, aiming to contribute to developing novel whitening products.

Indexed as

bioactive peptidesexcessive depositioninhibitionmelanintyrosinasewhitening

Identifiers

PMID40672371
PMCPMC12263694

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.