Evidence map›Paper›PMID 40673073›Full record

ReviewTranslational lung cancer research2025

Research progress on lung cancer complicated with pulmonary tuberculosis: a narrative review.

Ze-Jun Zhou, Hai-Yan Xie, Luca Bertolaccini, Ning Xia, Yu Zhang

Abstract readReview
In one paragraph

Review in Translational lung cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ze-Jun Zhou *Department of Respiratory Medicine, Nanjing Chest Hospital, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Hai-Yan Xie *Department of Respiratory Medicine, Nanjing Chest Hospital, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Luca BertolacciniDepartment of Thoracic Surgery, IEO, European Institute of Oncology IRCCS, Milan, Italy.
Ning XiaDepartment of Respiratory Medicine, Nanjing Chest Hospital, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.
Yu ZhangDepartment of Respiratory Medicine, Nanjing Chest Hospital, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objective: Pulmonary tuberculosis (PTB) and lung cancer (LC) are both serious health threats and have a complex relationship. Research has shown that tuberculosis (TB) may induce LC through chronic inflammation. TB infection is also more common in LC patients than in the general population. Patients with LC and TB have a higher rate of misdiagnosis, missed diagnosis, and a worse prognosis. Thus, the diagnosis and treatment of patients with LC and TB are highly challenging. This narrative review aims to provide some information for clarification on the relationship between LC and TB. Methods: We searched for retrospective cohort studies, observational studies, systematic reviews, and meta-analyses published between the database's inception and 2024 to retrieve relevant articles on TB and LC from the PubMed/MEDLINE database. Key Content and Findings: We outline the latest research on the relationship between pulmonary TB and LC, potential biological mechanisms, as well as the co-treatment of TB and the tumor. Conclusions: Chronic inflammatory stimulation, scar formation, DNA damage, immune dysfunction, and other mechanisms caused by TB are associated with the development and progression of LC. LC may also reactivate TB. Currently, there is no standard diagnosis and treatment plan for co-existent TB and LC. The fundamental principle of patient management is to balance anti-tumor and anti-TB treatments based on the patient's physical condition and make comprehensive intervention decisions.

Indexed as

immune checkpoint inhibitors (ICIs)immunotherapylung cancer (LC)targeted drugsTuberculosis (TB)

Identifiers

PMID40673073
PMCPMC12261255

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.