ArticleTranslational lung cancer research2025
Cytokine-driven modulation of WT1 and IL-10 in lung cancer progression.
Article in Translational lung cancer research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Therapeutic mRNA vaccines for lung cancer: reshaping the tumor microenvironment to enhance anti-tumor immunity.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Lung cancer is driven by complex interactions between oncogenes and the inflammatory microenvironment. In particular, the cytokines tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β), and their modulation of key regulators like Wilms' tumor 1 (WT1) and interleukin-10 (IL-10) remain underexplored. This study aims to investigate the role of these cytokines in WT1 and IL-10 regulation during lung cancer progression. Methods: A total of 982 lung cancer patient samples from The Human Protein Atlas were analyzed. Results: WT1 expression progressively increased from stage I to IV lung cancer and positively correlated with IL-10 in stages II and IV. WT1 overexpression in RAW264.7 cells treated with LPS led to a 12.9-fold increase in IL-10 expression. Proinflammatory cytokines decreased WT1 in A549 and B16-F10 cells but increased it in J774.2 macrophages, leading to cytoplasmic localization and phosphorylation. Patient sample analysis revealed a positive correlation between WT1 and IL-10 in advanced stages. Conclusions: These findings suggest that WT1 and IL-10 are modulated by inflammatory cytokines in a stage-dependent manner in lung cancer. WT1 upregulation is associated with increased IL-10 expression, particularly in advanced stages, highlighting potential therapeutic targets for modulating the immune response in lung cancer.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.