ReviewMaterials today. Bio2025
Beyond natural silk: Bioengineered silk fibroin for bone regeneration.
Review in Materials today. Bio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Application of Transgenic Silk Fibroin to Biomaterials.Biotechnology and bioengineering · 2026Review
- Biomaterial-assisted gene therapy for bone repair.Materials today. Bio · 2026Review
- Stem Cells to Organoids: Pioneering the Future of Regenerative Therapies.Stem cell reviews and reports · 2026Review
- Bioinspired and smart material systems for auricular cartilage engineering: toward microenvironment-responsive and self-regulating scaffolds.Regenerative biomaterials · 2026Review
- Recent progress of 3D printed responsive scaffolds for bone repair: A review.Materials today. Bio · 2025Review
- Biomimetic Silk Fibroin Scaffolds Functionalized with Hydroxyapatite and Platelet Growth Factors for Bone Tissue Engineering.Biomimetics (Basel, Switzerland) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone regeneration and repair are among the most challenging clinical challenges to overcome. Despite extensive research on bone-tissue repair and regeneration, it remains difficult to achieve perfect regeneration and repair of bone tissue using the current treatments. One new treatment is bone-tissue engineering (TE), which has attracted attention because of its low invasiveness. Silk fibroin (SF), a high-molecular-weight natural fibrous protein secreted by silkworms and spiders, is an ideal choice for melt electrowriting (MEW) of bone TE scaffolds owing to its superior mechanical properties, controlled biodegradation rate, and high biocompatibility. It contains 18 essential amino acids and is widely used in bone grafting. Their physical and chemical properties may be essential for stem cell growth and differentiation, making them ideal scaffold materials for bone TE. In this review, the three primary components of bone TE and the bone-healing process are presented. With an emphasis on recent advancements and the use of bone TE, both in
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Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.