Evidence map›Paper›PMID 40673159›Full record

ArticleMolecular therapy. Nucleic acids2025

microRNA-497-5p-based screening identifies a novel synthetic lethal-type interaction via PKMYT1 and WEE1 in pleural mesothelioma.

Nathanael Pruett, Sierra Wilferd, Anand Singh, Agnes Y Choi, Shivani Dixit, Vivek Singh, Charlize Nguyen, Olivia Lin, David S Schrump, Christopher L Plaisier and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Nucleic acids, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Nathanael PruettThoracic Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Sierra WilferdSchool of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ 85287, USA.
Anand SinghThoracic Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Agnes Y ChoiThoracic Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Shivani DixitThoracic Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Vivek SinghThoracic Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Charlize NguyenThoracic Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Olivia LinThoracic Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
David S SchrumpThoracic Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Christopher L PlaisierSchool of Biological and Health Systems Engineering, Arizona State University, Tempe, AZ 85287, USA.
Chuong D HoangThoracic Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Funding

microRNA regulatory networks in thoracic cancersZIABC011657 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI HOANG, CHUONG · 2015 to 2025
$18.1M
Epigenetic Mechanisms of Gene Expression in Thoracic MalignanciesZIABC011115 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SCHRUMP, DAVID · 2009 to 2025
$15.1M
Intramural NIH HHS ZIA BC011115Intramural NIH HHS ZIA BC011657
6 · The paper itself

Abstract

Diffuse pleural mesothelioma (DPM) is an incurable surface neoplasm governed by tumor suppressor losses with limited therapeutic options. Despite the advantages of leveraging the tumor suppressive activity of microRNA (miRNA/miR), clinical translation remains limited due to incomplete understanding of their context-specific gene targets. Here, we employed a biotinylated-miRNA pull-down approach to systematically identify direct targets of miR-497-5p, an miRNA markedly downregulated in DPM. Surprisingly, multiple identified targets were not predicted by

Indexed as

apoptosiscell cyclemesotheliomamicroRNAMT: Non-coding RNAsnanocomposite hydrogelsynthetic lethalitytumor suppressor

Identifiers

PMID40673159
PMCPMC12266497

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.