ArticleNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2025
Prevalence of reduced eGFR in European adults using KDIGO and age-adapted eGFR thresholds.
Article in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- The updated global burden of chronic kidney disease: one death every 20 seconds.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026Review
- Keller/eGFR ratio as a simple and useful tool to make a first differentiation between renal aging and chronic nephropathy in large populations.International urology and nephrology · 2026Review
- Prevalence of Hyperkalemia in a Contemporary European Cohort According to EKFC eGFR Categories.Diagnostics (Basel, Switzerland) · 2026Article
- ERA's ABCDE framework for kidney disease prevention: turning the WHO kidney health resolution into action.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2026Article
- Sex and Gender Differences in Chronic Kidney Disease-Explained by the Brenner-Luyckx Concept of Hyperfiltration.Journal of clinical medicine · 2026Review
- Chronic kidney disease screening to reduce cardiovascular risk: a call to action.American journal of preventive cardiology · 2026Article
- Impact of Adopting the Race/Ethnicity-Free 2021 CKD-EPI Equation on Cardiovascular Risk Stratification in a Multiethnic European Population: Results from the HELIUS Study.Global heart · 2026Article
- Circulating and Urinary CCL20 in Human Kidney Disease.International journal of molecular sciences · 2025Article
- Impact of switching from the CKD-EPIClinical kidney journal · 2025Article
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19 authors.
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Abstract
backgroundThe current definition for chronic kidney disease (CKD) does not account for age-related kidney function decline. Age-adapted CKD definitions have been suggested, but their impact on the estimates of reduced kidney function prevalence remains unclear. We aimed to compare the prevalence of reduced estimated glomerular filtration rate (eGFR) in European adults using the KDIGO eGFR threshold and three age-adapted eGFR thresholds.
methodsThis cross-sectional study included data collected after 1999 from nine general population-based studies from seven European countries. eGFR was calculated using the European Kidney Function Consortium equation. Prevalence of reduced eGFR was estimated over age using four eGFR thresholds: the KDIGO eGFR threshold (eGFR <60 mL/min/1.73 m2), the categorical age-adapted eGFR threshold (eGFR <75 mL/min/1.73 m2 if aged <40 years, eGFR <60 mL/min/1.73 m2 if aged 40-65 years, eGFR <45 mL/min/1.73 m2 if aged >65 years), and two novel continuous age- and sex-adapted eGFR thresholds based on the 5th and 2.5th percentile of eGFR in healthy individuals.
resultsWe used data from over 2.5 million European adults (46% men). Among those under 40 years, the KDIGO threshold provided the lowest average prevalence estimate (<1%), followed by the categorical age-adapted threshold (3%) and the 2.5th and 5th continuous age- and sex-adapted thresholds (4% and 7%). In adults over 65 years, the 2.5th continuous age- and sex-adapted threshold (10%) estimated the lowest prevalence, followed by the 5th continuous age- and sex-adapted threshold (15%), categorical age-adapted threshold (19%) and KDIGO threshold (45%).
conclusionUsing age-adapted eGFR thresholds would likely cause a shift in the prevalence of reduced kidney function. However, the association between these novel age-adapted thresholds and clinical outcomes needs to be established before considering their incorporation into the definition of CKD.
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