ArticleeLife2025
POMC neurons control fertility through differential signaling of MC4R in kisspeptin neurons.
Registry-linked trialAbstract read
In one paragraph
Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07674290 (Real-World Effectiveness, Safety and Patient-reported Outcomes of Setmelanotide in Patients With Bardet-Biedl Syndrome), which is not on this map. Cited by 10 papers.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Real-World Effectiveness, Safety and Patient-reported Outcomes of Setmelanotide in Patients With Bardet-Biedl Syndrome: A Prospective Mono Centric Observational Interventional Study
Who cites it
10 citing papers in PubMed.
- Effects of Maternal Zinc Deficiency and Post-Weaning Zinc Status on Neuroendocrine Markers Associated with Pubertal Regulation in Female Rat Offspring.International journal of molecular sciences · 2026Article
- Hypothalamic control of puberty: from neuronal circuits to mechanisms for its metabolic regulation.Reviews in endocrine & metabolic disorders · 2026Review
- Early-life programming of hypothalamic circuits by maternal obesity: implications for neuroendocrine disorders.Reviews in endocrine & metabolic disorders · 2026Review
- Regulatory risk loci link disrupted androgen response to the pathophysiology of polycystic ovary syndrome.Journal of the Endocrine Society · 2026Article
- Integrating mechanistic models to decode the GnRH pulse generator in female mice.Journal of molecular endocrinology · 2026Review
- The complex interaction between obesity and puberty and its implications for pubertal timing: a review of recent evidence.Endocrine connections · 2026Review
- Examining a central mechanism whereby undernutrition inhibits GnRH secretion via KNDy neurons.The Journal of reproduction and development · 2026Review
- Activity of arcuate kisspeptin/neurokinin B neurons and the melanocortin system during pubertal development in female sheep†.Biology of reproduction · 2025Article
- Melanocortin-responsive Kiss1 neurons of the arcuate nucleus drive energy expenditure through glutamatergic signaling to the dorsomedial hypothalamus.bioRxiv : the preprint server for biology · 2025Article
- Setmelanotide-mediated MC4R activation improves hypothalamic obesity via CaMKK2/AMPK pathways.Frontiers in pharmacology · 2025Article
Corrections and comments
- Update of
Authors and funding
12 authors.
Rajae Talbi *Harvard Medical School, Boston, United States.ORCID https://orcid.org/0000-0001-7158-6246
Todd L Stincic *Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, United States.ORCID https://orcid.org/0000-0001-7504-2422
Kaitlin FerrariDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Boston, United States.
Choi Ji Hae *Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Boston, United States.
Karol WalecDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Boston, United States.
Elizabeth MedveDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Boston, United States.
Achi GerutshangDivision of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Boston, United States.
Silvia LeonHarvard Medical School, Boston, United States.
Elizabeth A McCarthyHarvard Medical School, Boston, United States.
Oline K RønnekleivDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, United States.ORCID https://orcid.org/0000-0003-1841-4386
Martin J KellyDepartment of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, United States.ORCID https://orcid.org/0000-0002-8633-2510
Victor M NavarroHarvard Medical School, Boston, United States.ORCID https://orcid.org/0000-0002-5799-219X
Funding
The roles of NK3RMnPO and KNDy neurons in vasomotor symptoms, sleep, and cognition in E2 depleted mice.U54AG062322 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI Ursula B. Kaiser · 2020 to 2026
$13.7MTestosterone-GnRH Frequency and the Evolution of PCOS in AdolescenceP50HD028934 · NICHD · UNIVERSITY OF VIRGINIA · PI MCCARTNEY, CHRISTOPHER ROLLAND · 2014 to 2018
$8.6MSex Differences in the Control of FeedingR01DK068098 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI KELLY, MARTIN JEFFREY, RØNNEKLEIV, OLINE KARIN · 2005 to 2024
$7.1MCharacterization of the role of the amygdala in reproductive functionR01HD099084 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI NAVARRO, VICTOR MANUEL · 2020 to 2024
$2.3MCharacterization of Kiss1 neurons as mediators of the reproductive regulation of energy balanceR01DK133760 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI NAVARRO, VICTOR MANUEL · 2022 to 2025
$2.2MDissecting the Role of Tachykinins in the Generation of GnRH PulsesR01HD090151 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI NAVARRO, VICTOR MANUEL · 2017 to 2021
$1.7MIdentification of the Neuroprotective STX Receptor in the BrainR21AG080057 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KELLY, MARTIN JEFFREY, SCHULTZ, CARSTEN · 2023 to 2024
$424kCrosstalk between Estrogen and Metabolic Hormone Signaling in Kisspeptin NeuronsR56DK068098 · NIDDK · OREGON HEALTH & SCIENCE UNIVERSITY · PI KELLY, MARTIN JEFFREY, RØNNEKLEIV, OLINE KARIN · 2020 to 2020
$262kCharles A. King Trust Postdoctoral Research Fellowship AwardLalor Foundation Postdoctoral Research Fellowship AwardNIA NIH HHS R21 AG080057NIA NIH HHS U54 AG062322NICHD NIH HHS P50 HD028934NICHD NIH HHS R01 HD090151NICHD NIH HHS R01 HD099084NIDDK NIH HHS R01 DK068098NIDDK NIH HHS R01 DK133760NIDDK NIH HHS R56 DK068098NIH HHS R01DK068098NIH HHS R01DK133760NIH HHS R01HD090151NIH HHS R01HD099084NIH HHS U54AG062322
Abstract
Inactivating mutations in the melanocortin 4 receptor (
Indexed as
FertilityKisspeptinsNeuronsPro-OpiomelanocortinReceptor, Melanocortin, Type 4Signal TransductionAnimalsFemaleGonadotropin-Releasing HormoneLuteinizing HormoneMiceMice, KnockoutGonadotropin-Releasing HormoneKiss1 protein, mouseKisspeptinsLuteinizing HormoneMC4R protein, mousePro-OpiomelanocortinReceptor, Melanocortin, Type 4kisspeptinmelanocortinmouseneurosciencePOMCreproduction
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT07674290ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.