Evidence map›Paper›PMID 40674131›Full record

ArticleeLife2025

Decoding protein phosphorylation during oocyte meiotic divisions using phosphoproteomics.

Leonid Peshkin, Enrico Maria Daldello, Elizabeth S Van Itallie, Matthew Sonnett, Johannes Kreuzer, Wilhelm Haas, Marc W Kirschner, Catherine Jessus

Abstract read
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Leonid Peshkin *Systems Biology Department, Harvard Medical School, Boston, United States.ORCID https://orcid.org/0000-0002-6420-848X
Enrico Maria Daldello *Sorbonne Université, CNRS, Laboratoire de Biologie du Développement - Institut de Biologie Paris Seine, Paris, France.ORCID https://orcid.org/0000-0002-0456-8950
Elizabeth S Van ItallieSystems Biology Department, Harvard Medical School, Boston, United States.
Matthew SonnettSystems Biology Department, Harvard Medical School, Boston, United States.ORCID https://orcid.org/0000-0002-6795-1308
Johannes KreuzerSystems Biology Department, Harvard Medical School, Boston, United States.ORCID https://orcid.org/0000-0003-4716-2843
Wilhelm HaasSystems Biology Department, Harvard Medical School, Boston, United States.
Marc W KirschnerSystems Biology Department, Harvard Medical School, Boston, United States.ORCID https://orcid.org/0000-0001-6540-6130
Catherine JessusSorbonne Université, CNRS, Laboratoire de Biologie du Développement - Institut de Biologie Paris Seine, Paris, France.ORCID https://orcid.org/0000-0001-9296-6336

Funding

XenCAT: Xenopus Single Cell AtlasR24OD031956 · OD · HARVARD MEDICAL SCHOOL · PI PESHKIN, LEON · 2022 to 2025
$3.5M
Agence Nationale de la Recherche 18-CE13-0013-01Agence Nationale de la Recherche 23-CE12-0045-01Fondation ARC pour la Recherche sur le Cancer ARCPJA2023080006901NIH HHS R24 OD031956Sorbonne Université Emergence
6 · The paper itself

Abstract

Oocyte meiotic divisions represent a critical process in sexual reproduction, as a diploid non-dividing oocyte is transformed into a haploid fertilizable egg, as a prelude for the subsequent embryonic divisions and differentiation. Although cell differentiation and proliferation are governed by transcription, oocyte maturation and early embryonic divisions depend entirely on changes in protein abundance and post-translational modifications. Here, we analyze the abundance and phosphorylation of proteins during

Indexed as

MeiosisOocytesPhosphoproteinsProteomicsXenopus ProteinsAnimalsCDC2 Protein KinaseFemalePhosphorylationProtein Processing, Post-TranslationalXenopus laevisCDC2 Protein KinasePhosphoproteinsXenopus Proteinsbiochemistrycell biologychemical biologymeiotic maturationoocytephosphoproteomexenopus

Identifiers

PMID40674131
PMCPMC12270485

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.