Evidence map›Paper›PMID 40675146›Full record

ArticleCell reports2025

Transmission of maternal oral pathobionts to the infant gut predisposes offspring to exacerbated enteritis.

Masafumi Haraguchi, Yeji Kim, Natsuru Watanabe, Kyoko Yamazaki, Kira L Newman, Merritt G Gillilland, Yijie Guo, Daisuke Watanabe, Ingrid L Bergin, Takehiro Suzuki and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Masafumi HaraguchiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Yeji KimDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Natsuru WatanabeDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Kyoko YamazakiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Kira L NewmanDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Merritt G GillillandDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Yijie GuoDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Department of Psychiatry and Center for Brain Science, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Daisuke WatanabeDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Ingrid L BerginThe Unit for Laboratory Animal Medicine, University of Michigan, Ann Arbor, MI, USA.
Takehiro SuzukiWPI Immunology Frontier Research Center, The University of Osaka, Suita, Japan.
Daisuke MotookaNGS Core Facility, Bioinformatics Center, Research Institute for Microbial Diseases, The University of Osaka, Suita, Japan.
Kohei SugiharaWPI Immunology Frontier Research Center, The University of Osaka, Suita, Japan.
Sho KitamotoWPI Immunology Frontier Research Center, The University of Osaka, Suita, Japan.
Hiroko Nagao-KitamotoWPI Immunology Frontier Research Center, The University of Osaka, Suita, Japan. Electronic address: hirokita@ifrec.osaka-u.ac.jp.
Nobuhiko KamadaDivision of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; WPI Immunology Frontier Research Center, The University of Osaka, Suita, Japan; Department of Pathology, University of Michigan, Ann Arbor, MI, USA; Center for Infectious Disease Education and Research, The University of Osaka, Suita, Japan. Electronic address: nkamada@umich.edu.

Funding

The role of IL-1ß-inducing pathobionts in the pathogenesis of Crohn’s diseaseR01DK108901 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Nobuhiko Kamada · 2017 to 2026
$3.8M
The oral-gut axis in colorectal cancerR01CA288546 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Nobuhiko Kamada · 2024 to 2026
$1.7M
The link between oral bacteria and gut diseaseR01DK119219 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KAMADA, NOBUHIKO · 2019 to 2022
$1.6M
NCI NIH HHS R01 CA288546NIDDK NIH HHS R01 DK108901NIDDK NIH HHS R01 DK119219
6 · The paper itself

Abstract

Infants acquire maternal microbes from various body sites, which become early colonizers of the infant gut. Consequently, disruption of healthy maternal microbiota, particularly maternal gut dysbiosis, can influence the composition of offspring's gut microbiota and affect their health outcomes. However, the effects of non-gut maternal microbes on infant health and disease remain largely unexplored. Here, we demonstrate that maternal oral dysbiosis can have lasting health impacts on offspring. Ligature-induced periodontitis in mothers promotes the expansion of oral pathobionts, including Klebsiella aerogenes, which are transmitted to the infant gut, altering intestinal immunity and rendering offspring more susceptible to T cell-dependent enteritis. Notably, although these maternal oral pathobionts are eradicated as the microbiota matures, the imprinted susceptibility to enteritis persists into adulthood. Thus, maternal oral dysbiosis not only alters the early gut microbiota of infants but also may have long-term health implications for offspring.

Indexed as

EnteritisGastrointestinal MicrobiomeMouthAnimalsDysbiosisFemaleHumansInfantMaleMiceMice, Inbred C57BLPeriodontitisPregnancyCP: Microbiologygut microbiotainfant healthinflammatory bowel diseasematernal oral dysbiosismother-to-child microbiota transmissionoral microbiotaoral pathobionts

Identifiers

PMID40675146
PMCPMC12379185

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.