Evidence map›Paper›PMID 40675757›Full record

ArticleJournal of nuclear medicine : official publication, Society of Nuclear Medicine2025

[

Baosheng Chen, Chao Zheng, Tutukhanim Balayeva, Takuya Toyonaga, Xingxing Wang, Jie Tong, William Mennie, Jelena Mihailovic, Daniel Coman, Fahmeed Hyder and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. SV2A PET Imaging Detects Severity-Dependent Synaptic Changes After Experimental Traumatic Spinal Cord Injury.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  2. Review of Recent Advances in Implantable Brain-Computer Interfaces for the Restoration of Motor Function in Patients With Paralysis.Medical science monitor : international medical journal of experimental and clinical research · 2026
    Review
  3. Article
  4. High-resolution in utero SV2A PET imaging of the nonhuman primate brain using the NeuroEXPLORER.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  5. SV2A PET reveals synaptic density loss in experimental autoimmune encephalomyelitis and in a pilot multiple sclerosis study.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Baosheng ChenDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut.
Chao ZhengDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut.
Tutukhanim BalayevaDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut.
Takuya ToyonagaDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut.
Xingxing WangDepartments of Neuroscience and Neurology, Yale University, New Haven, Connecticut.
Jie TongDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut.
William MennieDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut.
Jelena MihailovicDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut.
Daniel ComanDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut.
Fahmeed HyderDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut.
Stephen M StrittmatterDepartments of Neuroscience and Neurology, Yale University, New Haven, Connecticut.
Richard E CarsonDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut.
Yiyun HuangDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut.
Zhengxin CaiDepartment of Radiology and Biomedical Imaging, Yale University, New Haven, Connecticut; jason.cai@yale.edu.

Funding

Prion Protein in Alzheimer's Disease PathophysiologyR01AG034924 · NIA · YALE UNIVERSITY · PI STEPHEN M STRITTMATTER · 2010 to 2026
$9.6M
Genome-Wide Discovery and Translational Research for Neural RepairR35NS097283 · NINDS · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2017 to 2024
$8.1M
SV2A PET in Spinal Cord Injury ImagingR01NS123183 · NINDS · YALE UNIVERSITY · PI Zhengxin Cai · 2022 to 2026
$3.3M
Synaptic selectivity for microglial-mediated damage in Alzheimer's DiseaseR01AG070926 · NIA · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2024 to 2025
$1.6M
NIA NIH HHS R01 AG034924NIA NIH HHS R01 AG070926NINDS NIH HHS R01 NS123183NINDS NIH HHS R35 NS097283
6 · The paper itself

Abstract

Traumatic spinal cord injury (SCI) is a devastating neurologic condition lacking effective prognostic and treatment methods. PET imaging of synaptic vesicle glycoprotein 2A (SV2A) has been used in measuring synapse changes. We explore the feasibility of using [

Indexed as

BrainMembrane GlycoproteinsNerve Tissue ProteinsPositron-Emission TomographySpinal CordSpinal Cord InjuriesAnimalsFemaleFluorine RadioisotopesMalePyridinesPyrrolidinesRatsRats, Sprague-DawleyFluorine RadioisotopesMembrane GlycoproteinsNerve Tissue ProteinsPyridinesPyrrolidinesSv2a protein, ratSynVesT-1[18F]SynVesT-1diffusion tensor imagingPETsimplified reference tissue model 2spinal cord injurySV2A

Identifiers

PMID40675757
PMCPMC12410297

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.