Evidence map›Paper›PMID 40675819›Full record

ArticleGenes & development2025

Speed of life: tuning the ticktock of the segmentation clock.

Sally Lowell

Abstract readComment
In one paragraph

Article in Genes & development, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Sally LowellCentre for Regenerative Medicine, Institute for Regeneration and Repair, Institute for Stem Cell Research, School of Biological Sciences, The University of Edinburgh, Edinburgh EH16 4UU, United Kingdom sally.lowell@ed.ac.uk.ORCID 0000-0002-4018-9480

Funding

Wellcome Trust 220298
6 · The paper itself

Abstract

Although vertebrates share a similar body plan, different vertebrate species can develop at very different rates. In recent years, there has been an increasing appreciation of the fact that protein stability regulates the pace of differentiation. For example, global differences in protein stability may help explain why humans develop more slowly than mice. Mechanisms controlling the stability of particular proteins are also likely to play a role. In keeping with this idea, in this issue of

Indexed as

Body PatterningReceptor, Notch1AnimalsCell DifferentiationGene Expression Regulation, DevelopmentalHumansMiceProtein StabilitySomitesReceptor, Notch1hiPSCNOTCH1PSMsegmentation clocksomitogenesissomitoid

Identifiers

PMID40675819
PMCPMC12404190

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.